Preparation

Using aseptic technique, dilute and prepare GOHIBIC for intravenous infusion before administration.

• For the recommended dose of 800 mg GOHIBIC, dilute 80 mL of GOHIBIC in 170 mL of 0.9% Sodium Chloride at room temperature.
• Use a 250 mL infusion bag of 0.9% Sodium Chloride solution USP and the follow steps below:
  • Withdraw 80 mL of 0.9% Sodium Chloride solution USP from the infusion bag and discard.
  • Withdraw the 80 mL of GOHIBIC from the vials and add slowly to the 0.9% Sodium Chloride solution USP infusion bag to a final concentration of 3.2 mg/mL.
  • To mix the solution, gently invert the bag to avoid foaming.

Storage of Diluted GOHIBIC

• Diluted GOHIBIC must be used within 4 hours when stored at room temperature 20°C to 25°C (68°F to 77°F).
• Diluted GOHIBIC stored under refrigeration at 2°C to 8°C (36°F to 46°F) must be used within 24 hours.
• After removal of diluted GOHIBIC from the refrigerator stored at 2°C to 8°C (36°F to 46°F), it must be left to acclimatize to room temperature prior to administration.

Administration

• Visually inspect for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if discoloration or visible particles are present.
• Administer diluted GOHIBIC via intravenous infusion over 30 - 60 minutes.
• Avoid concomitant administration of GOHIBIC with other drugs in the same intravenous line.