Drug Class: Viral vaccines
Usual Pediatric Dose for Hepatitis B Prophylaxis
Primary Vaccination:
Engerix-B(R): Three doses (10 mcg each), IM, on a 0, 1, and 6 month schedule
Recombivax HB(R): Three doses (5 mcg each), IM, on a 0, 1, and 6 month schedule
Known or Presumed Hepatitis B Exposure:
Use recommended doses (above) on a 0, 1, and 6 month schedule OR a 0, 1, 2, and 12 month schedule.
Comments:
- Administer hepatitis B immune globulin if appropriate.
- Start hepatitis B vaccine as soon as possible after exposure.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Alternate dosing schedules (Engerix-B(R)):
Birth to 10 years: 4 doses (10 mcg each), IM, on a 0, 1, 2, and 12 month schedule
5 to 16 years: 3 doses (10 mcg each), IM, on a 0, 12, and 24 month schedule
11 to 19 years: 3 doses (20 mcg each), IM, on a 0, 1, and 6 month schedule
11 to 19 years: 4 doses (20 mcg each), IM, on a 0, 1, 2, and 12 month schedule
Infants born of HBsAg-positive mothers: 4 doses (10 mcg each), IM, on a 0, 1, 2, and 12 month schedule
Alternate dosing schedule (Recombivax-HB(R)):
11 to 15 years: 2 doses (10 mcg each), IM, one initial dose, and a second dose 4 to 6 months later
Booster Vaccinations (when appropriate):
Engerix-B(R):
10 years and younger: booster dose is 10 mcg
11 years and older: booster dose is 20 mcg
Dialysis
Data not available
Other Comments
Administration advice:
- Administer IM; the preferred site is the anterolateral aspect of the thigh in patients under 1 year, and the deltoid muscle for older children and adults.
- Do not administer in the gluteal region: response may be suboptimal.
- Administer subcutaneously only in patients at risk of hemorrhage from IM injections.
Reconstitution/preparation techniques:
- Shake well before use to form a homogenous, turbid white suspension.
IV compatibility:
- Do not mix with any other vaccine or product in the same syringe/vial.
General:
- Health care providers should report any allergic or unusual adverse reactions to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 (USA) and the manufacturer.
