Subcutaneous Injection: HUMALOG U-100 or U-200

• ​Administer the dose of HUMALOG U-100 or HUMALOG U-200 within fifteen minutes before a meal or immediately after a meal by injection into the subcutaneous tissue of the abdominal wall, thigh, upper arm, or buttocks. To reduce the risk of lipodystrophy and localized cutaneous amyloidosis, rotate the injection site within the same region from one injection to the next. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis [see Warnings and Precautions (5.2) and Adverse Reactions (6)].
• ​During changes to a patient's insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)].
• HUMALOG administered by subcutaneous injection should generally be used in regimens with an intermediate- or long-acting insulin.
• The HUMALOG U-100 KwikPen, HUMALOG U-100 Tempo Pen and HUMALOG U-200 KwikPen each dial in 1 unit increments and delivers a maximum dose of 60 units per injection.
• The HUMALOG U-100 Junior KwikPen dials in 0.5 unit increments and delivers a maximum does of 30 units per injection.

Continuous Subcutaneous Infusion (Insulin Pump): HUMALOG U-100 ONLY

• Do NOT administer HUMALOG U-200 using a continuous subcutaneous infusion pump.
• ​Administer HUMALOG U-100 by continuous subcutaneous infusion in a region recommended in the instructions from the pump manufacturer. Rotate infusion sites within the same region to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis [see Warnings and Precautions (5.2) and Adverse Reactions (6)].
• ​During changes to a patient's insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)].
• Follow healthcare professional recommendations when setting basal and meal time infusion rate.
• Do NOT dilute or mix HUMALOG U-100 when administering by continuous subcutaneous infusion.
• Change HUMALOG U-100 in the pump reservoir at least every 7 days.
• Change the infusion sets and the infusion set insertion site at least every 3 days.
• Do NOT expose HUMALOG U-100 in the pump reservoir to temperatures greater than 98.6°F (37°C).
• Use HUMALOG U-100 in pump systems suitable for insulin infusion [see Patient Counseling Information (17)].

Intravenous Administration: HUMALOG U-100 ONLY

• Do NOT administer HUMALOG U-200 intravenously.
• Dilute HUMALOG U-100 to concentrations from 0.1 unit/mL to 1.0 unit/mL using 0.9% Sodium Chloride Injection, USP.
• Administer HUMALOG U-100 intravenously ONLY under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia [see Warnings and Precautions (5.3, 5.6) and How Supplied/Storage and Handling (16.4)].