Usual Adult Dose for Angina Pectoris Prophylaxis

IMMEDIATE RELEASE:
20 mg orally twice a day, 7 hours apart

Comments:

• Consider 5 mg twice daily for small statured patients; increase to at least 10 mg twice daily in first 2 to 3 days.
• Asymmetric dosing (7 hours apart) provides a nitrate-free interval to minimize tolerance.
• Start at the low end of the dosing range for elderly patients.
• Doses above 20 mg twice daily have not been adequately studied; 5 mg twice daily is clearly effective for only the first day.

Use: Prevention and treatment of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

EXTENDED RELEASE:
30 to 60 mg orally once a day in the morning

Maximum dose: 240 mg orally once a day in the morning

Comments:

• Swallow whole (do not crush or chew) with half-glass of fluid.
• Start at low end of dosing range for elderly patients.

Use: Prevention of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

Usual Adult Dose for Angina Pectoris

IMMEDIATE RELEASE:
20 mg orally twice a day, 7 hours apart

Comments:

• Consider 5 mg twice daily for small statured patients; increase to at least 10 mg twice daily in first 2 to 3 days.
• Asymmetric dosing (7 hours apart) provides a nitrate-free interval to minimize tolerance.
• Start at the low end of the dosing range for elderly patients.
• Doses above 20 mg twice daily have not been adequately studied; 5 mg twice daily is clearly effective for only the first day.

Use: Prevention and treatment of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

EXTENDED RELEASE:
30 to 60 mg orally once a day in the morning

Maximum dose: 240 mg orally once a day in the morning

Comments:

• Swallow whole (do not crush or chew) with half-glass of fluid.
• Start at low end of dosing range for elderly patients.

Use: Prevention of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

No adjustment recommended