2.2 Recommended Dosage
The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia.
Oral
The average total daily adult dose of KAYEXALATE is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily.
Rectal
The average adult dose is 30 g to 50 g every six hours.
2.3 Preparation and Administration
Prepare suspension fresh and use within 24 hours.
Do not heat KAYEXALATE as it could alter the exchange properties of the resin.
One level teaspoon contains approximately 3.5 g of KAYEXALATE and 15 mEq of sodium.
Oral Suspension
Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Administer with patient in an upright position [see Warnings and Precautions (5.4)].
Enema
After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place.
Administer as a warm (body temperature) emulsion in 100 mL of aqueous vehicle and flush with 50 to 100 ml of fluid. A somewhat thicker suspension may be used, but do not form a paste.
Agitate the emulsion gently during administration. The resin should be retained for as long as possible and follow by a cleansing enema with a nonsodium containing solution. Ensure an adequate volume of cleansing solution (up to 2 liters) is utilized.
