Androgens and anabolic steroids
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Kyzatrex Dosage

Drug Detail:Kyzatrex (Testosterone oral [ tes-tos-ter-one ])

Generic Name: TESTOSTERONE UNDECANOATE 100mg

Dosage Form: capsule, liquid filled

Drug Class: Androgens and anabolic steroids

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Important Dosage Information

KYZATREX™ is not substitutable with other oral testosterone undecanoate products.

Confirmation of Hypogonadism Before Initiation of KYZATREX™

Prior to initiating KYZATREX™, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these testosterone concentrations are below the normal range.

Recommended Dosage and Administration

Individualize the dosage of KYZATREX™ based on the patient's serum testosterone concentration response to the drug.

The recommended starting dose is 200 mg orally twice daily, once in the morning and once in the evening. Take KYZATREX™ with food.

Dosage Adjustment

Check serum testosterone concentrations 7 days after starting treatment or after dosage adjustment, 3 to 5 hours after the morning dose. Adjust the KYZATREX™ dose as necessary as shown in Table 1. Thereafter, periodically monitor serum testosterone concentrations.

The minimum recommended dose is 100 mg once daily in the morning. The maximum recommended dose is 400 mg twice daily. For total daily doses greater than 100 mg, administer the same dose in the morning and evening.

Table 1: KYZATREX™ Dosage Adjustment Scheme
Serum Testosterone Concentration Current KYZATREX™ Dosage New KYZATREX™ Dosage
Less than 460 ng/dL 100 mg with breakfast only 100 mg twice daily with meals
100 mg twice daily with meals 200 mg twice daily with meals
200 mg twice daily with meals 300 mg twice daily with meals
300 mg twice daily with meals 400 mg twice daily with meals
460 to 971 ng/dL No Dosage Change
More than 971 ng/dL 400 mg twice daily with meals 300 mg twice daily with meals
300 mg twice daily with meals 200 mg twice daily with meals
200 mg twice daily with meals 100 mg twice daily with meals
100 mg twice daily with meals 100 mg with breakfast only
100 mg with breakfast only Discontinue treatment
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