Usual Adult Dose for Intraocular Hypertension

0.25% solution: One to two drops in the affected eye(s) twice a day
0.5% solution: One to two drops in the affected eye(s) once a day

Comments:

• In patients with more severe or uncontrolled glaucoma, the 0.5% solution can be administered twice a day.
• If intraocular pressure is not at a satisfactory level, concomitant therapy with dipivefrin and/or epinephrine, and/or pilocarpine and other miotics, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be instituted.
• Patients should not use two or more topical ophthalmic beta-adrenergic blocking drugs concomitantly.

Usual Adult Dose for Glaucoma (Open Angle)

0.25% solution: One to two drops in the affected eye(s) twice a day
0.5% solution: One to two drops in the affected eye(s) once a day

Comments:

• In patients with more severe or uncontrolled glaucoma, the 0.5% solution can be administered twice a day.
• If intraocular pressure is not at a satisfactory level, concomitant therapy with dipivefrin and/or epinephrine, and/or pilocarpine and other miotics, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be instituted.
• Patients should not use two or more topical ophthalmic beta-adrenergic blocking drugs concomitantly.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

• Protect from light
• Do not store above 25 C (77 F)

• The systemic absorption may be reduced when using nasolacrimal occlusion or closing the eyelids for 2 minutes.