Usual Adult Dose for Diabetes Type 2

Recommended dose: 5 mg orally once a day

Comments: When used in combination with insulin or an insulin secretagogue, a lower dose of the insulin secretagogue or insulin may be necessary to reduce the risk of hypoglycemia.

Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Renal Dose Adjustments

No dose adjustment recommended.

Liver Dose Adjustments

No dose adjustment recommended.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

No adjustment recommended.

Other Comments

Administration advice:

• May take with or without food

• May be used as monotherapy or as add-on combination therapy with other glucose lowering agents, including insulin.
• Not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.

• Monitor for signs and symptoms of pancreatitis
• Monitor glycemic control

• Instruct patient to report signs and symptoms of pancreatitis; if persistent, severe abdominal pain occurs, seek medical advice promptly.
• Serious allergic reactions may occur; if symptoms occur, seek medical advice promptly.
• Hypoglycemia may occur, more commonly when used in combination with insulin or a sulfonylurea.
• Instruct patients to contact their health care provider if they develop severe and persistent joint pain or blisters or erosions of the skin.