​Administration of Dispersed Tablets or Crushed Tablets by Mouth

1. ​Place the appropriate number of tablets for the prescribed dose into a suitable container. If desired, the tablets may be crushed. Add the appropriate volume of drinking water (other liquids have not been tested) to make a suspension (see Table 1 below).

   Table 1: Number of Tablets and Volume of Drinking Water Needed to Make a Suspension for Administration of Dispersed or Crushed Tablets by Mouth

   ​Recommended Dosage	Number of 200 mg Tablets	Volume of Drinking Water
   ​400 mg	Two	30 mL
   ​800 mg	Four	60 mL
   ​1,200 mg	Six	90 mL

2. ​ Swirl the container gently to keep the particles from settling, and administer the suspension before it settles. The mixture will have a bitter taste.
3. ​Rinse the container with 15 mL of drinking water and administer the rinse water.
4. ​Repeat Step 3. Visually confirm that no particles are left in the container. If particles remain, repeat Step 3.

​Administration of Dispersed Tablets through a Nasogastric (NG) or Orogastric (OG) Tube

1. ​Remove the cap (if applicable) and plunger out of a 50 or 60 mL catheter-tip compatible syringe or equivalent. Add two tablets into the syringe body and place the plunger back in the syringe. Only two tablets can be administered via NG or OG tube at a time.
2. ​Draw 30 mL of drinking water (other liquids have not been tested) into the syringe and hold the syringe with the tip pointing upward. Pull the plunger further to a higher volume position to have some air space in the syringe. Place the cap back on the syringe (if applicable). Shake the syringe well (careful not to spill the contents) for about 30 to 45 seconds or until the tablets are completely dispersed.
3. ​Once the tablets are completely dispersed in the syringe, remove the cap from the syringe again (if applicable) and attach the syringe to the NG or OG tube and administer the dispersion before it settles.
4. ​Draw 15 mL of water using the same syringe and flush through the same NG or OG tube.
5. ​Repeat Step 4 and make sure no particles are left in the syringe by visual inspection. If particles remain, repeat Step 4.
6. ​For doses of 800 mg (four 200 mg tablets) and 1,200 mg (six 200 mg tablets) [see Dosage and Administration (2.2)], repeat Steps 1-5 until prescribed dose is reached. The same syringe, NG or OG tube can be used.