Usual Pediatric Dose for Pediatric Growth Hormone Deficiency

1 year and older and weighing at least 11.5 kg:
Recommended dose: 0.24 mg/kg subcutaneously once a week

Comments:

• Individualize dose based on response.
• Round dose to closest cartridge dose while considering treatment goals and patient response.
• If no increase in height velocity, particularly during the first year of treatment, assess compliance and evaluate other causes of poor growth such as hypothyroidism, undernutrition, advanced bone age and antibodies to recombinant human growth hormone.
• Discontinue once epiphyseal fusion has occurred.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Acute critical illness
• Hypersensitivity to any of the ingredients
• Children with closed epiphyses
• Active malignancy
• Active proliferative or severe non-proliferative diabetic retinopathy
• Children with Prader-Willi syndrome who are severely obese or have severe respiratory impairment due to risk of sudden death

Dialysis

Data not available

Other Comments

Administration advice:

• Rotate administration site to avoid lipoatrophy.

• Therapy should be supervised by a physician experienced in the diagnosis and management of pediatric growth failure due to growth hormone deficiency (GHD).
• To exclude preexisting papilledema, perform fundoscopic examination before initiating treatment and reassess periodically thereafter.