Usual Pediatric Dose for Primary IGF-1 Deficiency

Growth failure in children with severe primary Insulin-like Growth Factor-1 deficiency or with growth hormone gene deletion who have developed neutralizing antibodies to growth hormone.

3 years old to adult (closed epiphyses):
initial dose: 0.5 mg/kg once daily by subcutaneous injection. To establish tolerability, glucose monitoring should be considered at treatment initiation or when a dose has been increased. The dosage can be titrated up to the maximum of 2 mg/kg per day. Doses should be administered at approximately the same time each day. If the patient is unable to eat shortly before or after a dose for any reason, that dose should be withheld. Subsequent doses should never be increased to make up for one or more missed doses.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available