Recommended dose: 20 ppm
Duration of therapy: 14 days or until the underlying oxygen desaturation has resolved
Weaning off: Down-titrate in several steps, pausing several hours at each step to monitor for hypoxemia
Comments:
Doses above 20 ppm are not recommended
Avoid abrupt discontinuation
Use(s): To improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near term (over 34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
Neonates dependent on right-to-left shunting of blood
Safety and efficacy have not been established in patients other than term and near term neonates.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
Users of Nitric Oxide Delivery Systems must complete a comprehensive periodic training program provided by the delivery system and drug manufacturers.
Avoid abrupt discontinuation.
Storage requirements:
Store at controlled room temperature
Protect cylinders from shocks, falls, oxidizing and flammable materials, moisture, and sources of heat or ignition.
Monitoring:
Measure methemoglobin within 4 to 8 hours of treatment initiation and periodically throughout treatment.
