Ultrasound contrast media
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Optison Dosage

Drug Detail:Optison (Perflutren [ per-floo-tren ])

Generic Name: HUMAN ALBUMIN MICROSPHERES 10mg in 1mL, PERFLUTREN 0.22mg in 1mL

Dosage Form: injection, solution

Drug Class: Ultrasound contrast media

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosage

  • The recommended dose of OPTISON is 0.5 mL intravenously injected into a peripheral vein.
  • If the contrast enhancement is inadequate after the dose of 0.5 mL, additional doses in increments of 0.5 mL may be repeated for further contrast enhancement as needed.
  • The maximum total dose should not exceed 5 mL in any 10 minute period.
  • The maximum total dose should not exceed 8.7 mL in any one patient study.

Preparation Instructions

  • Do not use if the container has been damaged, the protective seal and/or rubber cap have been entered, or the upper white layer is absent (may indicate the microspheres have been damaged and may result in poor or no echo contrast).
  • Invert the OPTISON vial and gently rotate to resuspend the microspheres. This process will allow the product to come to room temperature (20° to 25°C or 68° to 77°F) before use.
  • Inspect the vial for complete resuspension. Do not use if the suspension appears to be clear rather than opaque and milky-white.
  • Vent the OPTISON vial with a sterile vent spike or with a sterile 18 gauge needle before withdrawing the OPTISON suspension into the injection syringe.
  • Do not inject air into the vial.
  • Use the product within one minute of suspension. If one minute is exceeded, resuspend by inverting and gently rotating the microsoheres in the syringe. Failure to adequately resuspend OPTISON may cause inadequate delivery of the microspheres, and may result in inadequate contrast.

Administration Instructions

  • Inspect visually for particulate matter and discoloration prior to administration, whenever supension and container permit. Do not inject if the suspension is not opaque, milky-white, and absent particulate matter.
  • Inject through a 20-gauge or larger angiocatheter into a peripheral vein at a rate not exceeding 1 mL per second. Suggested methods of administration include: a short extension tubing, heparin lock, or intravenous line, all with a 3-way stopcock.
  • Administer intravenously; do not administer OPTISON by intra-arterial injection [see Warnings and Precautions (5.3)] .
  • Do not aspirate blood back into the OPTISON containing syringe before administration; this may promote the formation of a blood clot within the syringe.
  • For short extension tubing or heparin lock: fill one syringe with 0.9% Sodium Chloride Injection, USP, and FLUSH the line for patency before and after the injection of OPTISON.
  • For a continuous intravenous line: open an intravenous line with 0.9% Sodium Chloride Injection, USP (or 5% Dextrose Injection, USP) at a slow infusion rate to maintain vascular patency. Flush the line immediately after injection of OPTISON.
  • Do not use the single-patient use vial for more than one patient. Discard unused product.
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