Usual Adult Dose for Bacterial Infection

Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Use: For the treatment of infections due to susceptible penicillinase-producing staphylococci

Usual Adult Dose for Endocarditis

American Heart Association (AHA) Recommendations:

• Native valve infective endocarditis (NVE): 2 g IV every 4 hours OR 3 g IV every 6 hours
• Prosthetic valve endocarditis: 2 g IV every 4 hours

• For complicated right-sided NVE and for left-sided NVE: 6 weeks
• For uncomplicated right-sided NVE: 2 weeks
• For prosthetic valve endocarditis: At least 6 weeks

• Recommended for NVE due to oxacillin-susceptible strains of staphylococci
• With other agents, recommended for endocarditis involving prosthetic valve (or other prosthetic material) due to oxacillin-susceptible strains of staphylococci
• Current guidelines should be consulted for additional information.

Usual Adult Dose for Joint Infection

Infectious Diseases Society of America (IDSA) Recommendations: 1.5 to 2 g IV every 4 to 6 hours

Comments:

• Recommended as a substitute for nafcillin to treat prosthetic joint infection due to oxacillin-susceptible staphylococci
• Current guidelines should be consulted for additional information.

Usual Adult Dose for Meningitis

IDSA Recommendations: 9 to 12 g/day IV divided every 4 hours

Comments:

• Recommended as a standard regimen for bacterial meningitis due to methicillin-susceptible Staphylococcus aureus
• Current guidelines should be consulted for additional information.

Usual Adult Dose for Osteomyelitis

IDSA Recommendations: 1.5 to 2 g IV every 4 to 6 hours
Duration of therapy: 6 weeks

Comments:

• Recommended as a preferred regimen for native vertebral osteomyelitis due to oxacillin-susceptible staphylococci
• Alternatively, the total daily dose may be administered via continuous infusion.
• Current guidelines should be consulted for additional information.

Usual Adult Dose for Skin or Soft Tissue Infection

IDSA Recommendations:

• Incisional surgical site infections: 2 g IV every 6 hours
• Skin and soft tissue infection, necrotizing infections: 1 to 2 g IV every 4 hours

• Recommended for treatment of incisional surgical site infections associated with surgery of trunk or extremity away from axilla or perineum
• Recommended as a preferred regimen for skin and soft tissue infection due to methicillin-susceptible S aureus and necrotizing infections of the skin, fascia, and muscle due to S aureus
• Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Bacterial Infection

Premature and neonates: 25 mg/kg/day IV or IM

Infants and children weighing less than 40 kg:

• Mild to moderate infections: 12.5 mg/kg IV or IM every 6 hours
• Severe infections: 100 mg/kg/day IV or IM in equally divided doses every 4 to 6 hours

• Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
• Severe infections: 1 g IV or IM every 4 to 6 hours

• Postnatal age up to 7 days: 25 mg/kg IV or IM every 12 hours
• Postnatal age greater than 7 days: 25 mg/kg IV or IM every 8 hours

• Postnatal age up to 7 days: 25 mg/kg IV or IM every 8 hours
• Postnatal age greater than 7 days: 25 mg/kg IV or IM every 6 hours

• Neonates: Higher doses may be needed for meningitis, though safety and efficacy data for dosing neonates with CNS infection are lacking.
• Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Endocarditis

AHA Recommendations:
1 year or older: 200 mg/kg/day IV divided every 4 to 6 hours
Maximum dose: 12 g/day
Duration of therapy: At least 4 to 6 weeks

Comments:

• Recommended as an alternative regimen for infective endocarditis due to staphylococci (S aureus or coagulase-negative staphylococci) susceptible to 1 mcg/mL or less penicillin G
• With or without gentamicin, recommended as a preferred regimen for infective endocarditis due to staphylococci (S aureus or coagulase-negative staphylococci) resistant to 0.1 mcg/mL penicillin G
• Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Meningitis

IDSA Recommendations:

• Neonates 0 to 7 days: 75 mg/kg/day IV divided every 8 to 12 hours
• Neonates 8 to 28 days: 150 to 200 mg/kg/day IV divided every 6 to 8 hours
• Infants and children: 200 mg/kg/day IV divided every 6 hours

• Recommended as a standard regimen for bacterial meningitis due to methicillin-susceptible S aureus
• Smaller doses and longer administration intervals may be advisable for very low birth weight neonates (less than 2 kg).
• Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Pneumonia

Pediatric Infectious Diseases Society and IDSA Recommendations:

• Infants and children older than 3 months: 150 to 200 mg/kg/day IV or IM divided every 6 to 8 hours

• Recommended as a preferred regimen for community-acquired pneumonia due to methicillin-susceptible S aureus
• Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Skin or Soft Tissue Infection

IDSA Recommendations:
1 month or older:

• Necrotizing infections: 50 mg/kg IV every 6 hours
• Skin and soft tissue infection: 100 to 150 mg/kg/day IV in 4 divided doses

• Recommended as a preferred regimen for necrotizing infections of the skin, fascia, and muscle due to S aureus
• Recommended as a preferred regimen for skin and soft tissue infection due to methicillin-susceptible S aureus
• Current guidelines should be consulted for additional information.

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• History of hypersensitivity (anaphylactic) reaction to any penicillin
• Dextrose-containing solutions: Known allergy to corn or corn products

Dialysis

Data not available

Other Comments

Administration advice:

• May administer IM, by direct IV injection (slowly over about 10 minutes), or as a continuous or intermittent IV infusion
• Do not use plastic container in series connections.
• If another agent is used concomitantly, do not physically mix with this drug; administer separately.
• Determine duration of therapy by clinical and bacteriological response of patient.
• Continue therapy for at least 14 days in severe staphylococcal infections.
• Continue therapy for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures.

• Galaxy containers: Store at or below -20C (-4F); thawed solution is stable for 21 days under refrigeration or 48 hours at room temperature; do not refreeze.
• Vials: Store at 20C to 25C (68F to 77F) before reconstitution; the manufacturer product information should be consulted regarding stability periods of reconstituted and/or further diluted solutions at room temperature (25C), under refrigeration (4C), or frozen (-15C).

• Galaxy containers: Thaw frozen container at room temperature (25C [77F]) or in refrigerator (5C [41F]); do not force thaw by immersion in water baths or by microwave irradiation.
• Vials: The manufacturer product information should be consulted.

• Compatible reconstitution diluents for vials: Sterile Water for Injection, USP; Sodium Chloride Injection, USP
• Compatible IV solutions for vials: Sterile Water for Injection, USP; 0.9% Sodium chloride Injection, USP; M/6 Molar Sodium Lactate Solution; 5% Dextrose in water; 5% Dextrose in 0.45% sodium chloride; 10% Invert Sugar Injection, USP; Lactated Ringers Solution; 5% Dextrose in Normal Saline; 10% D-Fructose in Water; 10% D-Fructose in Normal Saline; Lactated Potassic Saline Injection; 10% Invert Sugar in Normal Saline; 10% Invert Sugar Plus 0.3% Potassium Chloride in Water; Travert 10% Electrolyte #1; Travert 10% Electrolyte #2; Travert 10% Electrolyte #3
• Do not add supplementary medication.

• Bacteriologic studies recommended to verify causative organisms and susceptibility.
• Duration of therapy varies with type and severity of infection and overall patient condition; endocarditis and osteomyelitis may require a longer duration of therapy.
• Caution recommended with IV administration (especially in elderly patients) due to possibility of thrombophlebitis.

• General: Clinical and laboratory signs of toxic or adverse effects (pediatric patients); blood cultures (prior to and at least weekly during therapy); blood levels (renally impaired patients)
• Hematologic: White blood cell and differential cell counts (prior to and at least weekly during therapy); hematopoietic function (periodically during prolonged therapy)
• Hepatic: AST and ALT (periodically during therapy); hepatic function (periodically during prolonged therapy)
• Renal: Urinalysis, blood urea nitrogen, and creatinine (periodically during therapy); renal function in elderly patients; renal function (periodically during prolonged therapy)

• Avoid missing doses and complete the entire course of therapy.
• Contact physician as soon as possible if watery and bloody stools (with or without stomach cramps and fever) develop.