Usual Adult Dose for Pheochromocytoma

Initial dose: 10 mg orally twice daily
Maintenance dose: 20 to 40 mg orally 2 to 3 times daily until an optimal dosage (as judged by blood pressure control) is obtained.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The dosage should be adjusted to fit the needs of each patient. Increases in dosage should be made every other day, with careful observation of the patient after each increase. The dosage should be adjusted to a point where symptomatic relief and/or objective improvement are obtained, or until the side effects from blockade cannot be tolerated.

Precautions

Caution is recommended in patients with marked cerebral or coronary arteriosclerosis or renal damage.

The adrenergic blocking effect may aggravate symptoms of respiratory infections.

Safety and efficacy in pediatric patients have not been established.

Dialysis

Data not available

Other Comments

Concomitant use of a beta-blocking agent may be necessary if tachycardia is excessive.