Usual Adult Dose for Candidemia

Loading dose: 400 mg once by IV infusion
Maintenance dose: 200 mg once a week by IV infusion

• Administer IV infusion over approximately one hour (250 mL/hr).
• For infusion-related reactions, slow or pause infusion, and restart at a lower rate.

• It is recommended to obtain cultures prior to initiating antifungal therapy; adjust treatment appropriately once culture results are known.
• For IV use only; dilute prior to administration.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

No adjustment recommended.

Precautions

CONTRAINDICATIONS:

• In patients with known hypersensitivity to this drug or other echinocandins.

Dialysis

Drug is highly protein bound and not expected to be dialyzable.

Other Comments

Administration advice:

• The manufacturer product information should be consulted prior to product administration.
• Day 1 of treatment begins with loading dose; maintenance dose begins on Day 8.
• Dilute product prior to administration and give by IV infusion only; infuse over 1 hour.
• If infusion-related reactions occur, slow or pause the infusion, and then restart at a reduced rate.

• In general, administer missed doses (those not given on assigned day) as soon as possible.
• If a missed dose is given within 3 days of assigned day, then next weekly dose may be given on schedule.
• If a missed dose is given beyond 3 days after assigned day, revise dosing schedule to ensure at least 4 days before next dose.
• If restarting after 2 weeks of missed dosing, dosing schedule should begin with 400 mg loading dose.

• Vials: Store between 20C to 25C (68F to 77F); Brief excursions permitted to 5C to 30C (59F to 86F).
• Reconstituted solution: Store between 5C to 25C (41F to 77F) for up to 24 hours.
• IV infusion solution: Store between 5C to 25C (41F to 77F) for up to 48 hours; do not freeze.

• The manufacturer product information should be consulted prior to preparation for administration.
• Reconstitute vial with sterile water and swirl to dissolve; avoid shaking or foaming.
• Inspect for particulate matter; do not use if solution cloudy or has precipitated.
• Dilute reconstituted product in 250 mL of 0.9% or 0.45% sodium chloride, or 5% dextrose.

• This drug has not been studied in patients with endocarditis, osteomyelitis, and meningitis due to Candida.
• Antifungal activity has been demonstrated (in vitro and clinically) for the following microorganisms: C. albicans, C. glabrata, C. parapsilosis, C. tropicalis

• Monitor patients for infusion-related reactions during IV administration of this drug.
• Assess liver function and monitor patients who develop abnormal liver tests.
• Evaluate patients for hematological changes, such as anemia, during treatment.

• Counsel patients this drug may cause photosensitivity during treatment; UV protection is recommended.