Application and Removal Instructions

• Each transdermal system releases 3.1 mg of granisetron per 24 hours for up to 7 days.
• Each transdermal system is packed in a pouch and should be applied directly after the pouch has been opened.
• Only wear one transdermal system at any time.
• Do not cut the transdermal system.
• Open the pouch and apply the transdermal system to clean, dry, nearly hairless, intact healthy skin on the upper outer arm.
• Do not place Sancuso transdermal system on skin that is red, irritated, or damaged.
• Do not apply a heat pad or heat lamp over or in vicinity of the transdermal system and avoid extended exposure to heat [see Warnings and Precautions (5.4)].
• Cover the application site of the transdermal system with clothing, if there is a risk of exposure to direct natural or artificial sunlight throughout the period of wear and for 10 days following its removal [see Warnings and Precautions (5.5)].
• After the transdermal system is applied, wash hands thoroughly.
• Remove the transdermal system by peeling off gently from the skin.
• Upon removal, fold the transdermal system in half with the sticky side together, and discard in the household trash in a manner that prevents accidental contact or ingestion by children, pets or others.
• Sancuso contains granisetron. Do not use other granisetron-containing products with Sancuso.