Usual Adult Dose for Ocular Infection

Ointment: Apply a small amount (about 1/2 inch ribbon) into the conjunctival sac(s) of the infected eye(s) every 3 to 4 hours and at bedtime.
Solution: Instill 1 to 2 drops into the conjunctival sac(s) of the affected eye(s) every 2 to 3 hours initially.

Duration of therapy: 7 to 10 days

Comments:

• As the condition responds, may taper by increasing the time interval between doses
• May use the ointment as adjunct to the solution

Uses: For the treatment of conjunctivitis and other superficial ocular infections due to susceptible Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, Enterobacter species

Usual Adult Dose for Conjunctivitis

Ointment: Apply a small amount (about 1/2 inch ribbon) into the conjunctival sac(s) of the infected eye(s) every 3 to 4 hours and at bedtime.
Solution: Instill 1 to 2 drops into the conjunctival sac(s) of the affected eye(s) every 2 to 3 hours initially.

Duration of therapy: 7 to 10 days

Comments:

• As the condition responds, may taper by increasing the time interval between doses
• May use the ointment as adjunct to the solution

Uses: For the treatment of conjunctivitis and other superficial ocular infections due to susceptible Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, Enterobacter species

Usual Adult Dose for Trachoma

Solution: Instill 2 drops into the conjunctival sac(s) of the affected eye(s) every 2 hours.

Comments: For use with systemic therapy

Use: As an adjunct to systemic sulfonamide therapy of trachoma

Usual Pediatric Dose for Ocular Infection

2 months or older:

• Ointment: Apply a small amount (about 1/2 inch ribbon) into the conjunctival sac(s) of the infected eye(s) every 3 to 4 hours and at bedtime.
• Solution: Instill 1 to 2 drops into the conjunctival sac(s) of the infected eye(s) every 2 to 3 hours initially.

Duration of therapy: 7 to 10 days

Comments:

• As the condition responds, may taper by increasing the time interval between doses
• May use the ointment as adjunct to the solution

Uses: For the treatment of conjunctivitis and other superficial ocular infections due to susceptible E coli, S aureus, S pneumoniae, Streptococcus (viridans group), H influenzae, Klebsiella species, Enterobacter species

Usual Pediatric Dose for Conjunctivitis

2 months or older:

• Ointment: Apply a small amount (about 1/2 inch ribbon) into the conjunctival sac(s) of the infected eye(s) every 3 to 4 hours and at bedtime.
• Solution: Instill 1 to 2 drops into the conjunctival sac(s) of the infected eye(s) every 2 to 3 hours initially.

Duration of therapy: 7 to 10 days

Comments:

• As the condition responds, may taper by increasing the time interval between doses
• May use the ointment as adjunct to the solution

Uses: For the treatment of conjunctivitis and other superficial ocular infections due to susceptible E coli, S aureus, S pneumoniae, Streptococcus (viridans group), H influenzae, Klebsiella species, Enterobacter species

Usual Pediatric Dose for Trachoma

2 months or older:

• Solution: Instill 2 drops into the conjunctival sac(s) of the affected eye(s) every 2 hours.

Comments: For use with systemic therapy

Use: As an adjunct to systemic sulfonamide therapy of trachoma

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 2 months.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

• Ointment: Store at 20C to 25C (68F to 77F).
• Solution: Store at 8C to 25C (46F to 77F); protect from light.

General:

• Topically applied sulfonamides provide insufficient coverage against Neisseria species, Serratia marcescens, and Pseudomonas aeruginosa.
• A significant percentage of staphylococcal isolates are completely resistant to sulfa drugs.
• Sulfonamide solution color will darken over time and should be discarded.

Patient advice:

• Avoid contaminating the applicator tip through contact with the eye, eyelid, or any other surface.
• Discontinue therapy and contact physician at first sign of hypersensitivity, if purulent discharge increases, or if inflammation/pain worsens.