Usual Adult Dose for Intraocular Hypertension

One eye drop in the conjunctival sac of the affected eye(s) once a day in the evening

Comments:

• The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect.
• This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
• If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart.
• Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours.

• Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Usual Adult Dose for Glaucoma (Open Angle)

One eye drop in the conjunctival sac of the affected eye(s) once a day in the evening

Comments:

• The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect.
• This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
• If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart.
• Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours.

• Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

• Store in refrigerator (2 to 8 C/36 to 46 F)
• After the pouch is opened, the single-use containers may be stored in the opened foil pouch for up to 28 days at room temperature (20 to 25 C/68 to 77 F).
• Protect from moisture
• Protect from light
• Discard an opened single-dose container with any remaining solution immediately after use.

• You should wipe off any excess solution from the skin to reduce the risk of darkening of the eyelid skin.
• As with any other eye drops, nasolacrimal occlusion or gently closing the eyelid after administration is recommended. This may reduce the systemic absorption of medicinal products administered via the ocular route.
• If more than one topical ophthalmic medicinal product is being used, each one should be administered at least 5 minutes apart