Usual Adult Dose for Acute Coronary Syndrome

Initial dose: 25 mcg/kg IV within 5 minutes
Maintenance dose: 0.15 mcg/kg/min IV infusion for up to 18 hours

Use: To reduce the rate of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

Renal Dose Adjustments

CrCl greater than 60 mL/min: Data not available
CrCl 60 mL/min or less: Following usual bolus dose, initiate constant infusion at 0.075 mcg/kg/min.

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

• Do not freeze.
• Protect from light.

• Do not administer through the same IV line as diazepam.
• Do not add other drugs or remove solution directly with a syringe.
• Do not use plastic containers in series connections.

• Hematologic: Platelet counts, hemoglobin, and hematocrit prior to treatment, 6 hours after the initial dose, and daily thereafter; platelet counts to exclude pseudothrombocytopenia if platelets decrease to less than 90,000 cells/mm3; activated partial thromboplastin time (aPTT) prior to treatment and regularly thereafter to determine the anticoagulant effects of heparin.