Azole antifungals
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Tolsura Dosage

Drug Detail:Tolsura (Itraconazole [ it-ra-kon-a-zole ])

Generic Name: Itraconazole 65mg

Dosage Form: capsule, gelatin coated

Drug Class: Azole antifungals

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

TOLSURA must be administered with food.

TOLSURA capsules must be swallowed whole. Do not chew, crush or break TOLSURA capsules.

Table 1 below describes the recommended dosage for TOLSURA.

Table 1: Dosage and Administration of TOLSURA
Indications Daily Dosing
Treatment of Blastomycosis and Histoplasmosis
Recommended dose 130 mg (2 × 65 mg capsules) once daily
If no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 65 mg increments to a maximum of 260 mg/day (130 mg (2 × 65 mg capsules) twice daily). Doses above 130 mg/day should be given in two divided doses.
Treatment of Aspergillosis
Recommended dose 130 mg (2 × 65 mg capsules) once daily
260 mg/day (130 mg (2 × 65 mg capsules) twice daily)
Treatment in Life-Threatening Situations
Although clinical studies did not provide for a loading dose, it is recommended, based on pharmacokinetic data, that a loading dose should be used. A loading dose of 130 mg (2 × 65 mg capsules) three times daily (390 mg/day) is recommended to be given for the first 3 days, followed by the appropriate recommended dosing based on indication. Treatment should be continued for a minimum of three months and until clinical parameters and laboratory tests indicate that the active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection.
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