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Home > Drugs > Opioids (narcotic analgesics) > Ultram er > Ultram ER Dosage
Opioids (narcotic analgesics)
https://themeditary.com/dosage-information/ultram-er-dosage-4389.html

Ultram ER Dosage

Drug Detail:Ultram er (Tramadol [ tram-a-dol ])

Generic Name: TRAMADOL HYDROCHLORIDE 300mg

Dosage Form: tablet, extended release

Drug Class: Opioids (narcotic analgesics)

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Important Dosage and Administration Instructions

​ULTRAM ER should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.

•
​Do not use ULTRAM ER concomitantly with other tramadol products [see Warnings and Precautions (5.5​), (5.13​)].
•
​Do not administer ULTRAM ER at a dose exceeding 300 mg per day.
•
​Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5.6​)].
•
​Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see Warnings and Precautions (5.1​)]
•
​Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with ULTRAM ER and adjust the dosage accordingly [see Warnings and Precautions (5.2​)].
•
​Instruct patients to swallow ULTRAM ER tablets whole [see Patient Counseling Information (17​)]​, and to take it with liquid. Crushing, chewing, splitting, or dissolving ULTRAM ER tablets will result in uncontrolled delivery of tramadol and can lead to overdose or death [see Warnings and Precautions (5.1​)].
•
​ULTRAM ER may be taken without regard to food, It is recommended that ULTRAM ER be taken in a consistent manner [see Clinical Pharmacology(12.3)​].

Initial Dosage

​Patients Not Currently on a Tramadol Product

​The initial dose of ULTRAM ER is 100 mg once daily.

​Patients Currently on Tramadol Immediate-Release (IR) Products

​Calculate the 24-hour tramadol IR dose and initiate a total daily dose of ULTRAM ER rounded down to the next lower 100 mg increment. The dose may subsequently be individualized according to patient need.

​Due to limitations in flexibility of dose selection with ULTRAM ER, some patients maintained on tramadol IR products may not be able to convert to ULTRAM ER.

​Conversion from Other Opioids to ULTRAM ER

​Discontinue all other around-the-clock opioid drugs when ULTRAM ER therapy is initiated. There are no established conversion ratios for conversion from other opioids to ULTRAM ER defined by clinical trials. Initiate dosing using ULTRAM ER 100 mg once a day.

Titration and Maintenance of Therapy

​Individually titrate ULTRAM ER by 100 mg every five days to a dose that provides adequate analgesia and minimizes adverse reactions. The maximum daily dose of ULTRAM ER is 300 mg per day.

​Continually reevaluate patients receiving ULTRAM ER to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse [see Warnings and Precautions (5.1​)]. ​Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration. During chronic therapy, periodically reassess the continued need for the use of opioid analgesics.

​Patients who experience breakthrough pain may require a dosage adjustment of ULTRAM ER, or may need rescue medication with an appropriate dose of an immediate-release analgesic. If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the ULTRAM ER dosage.

​If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.

Discontinuation of ULTRAM ER

​When a patient no longer requires therapy with ULTRAM ER, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both. Do not abruptly discontinue ULTRAM ER [see Warnings and Precautions (5.16​), Drug Abuse and Dependence (9.3​)].

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