The recommended dosage of VIBERZI is 100 mg taken orally twice daily with food.

The recommended dosage of VIBERZI is 75 mg taken orally twice daily with food in patients:

• unable to tolerate the 100 mg dose of VIBERZI [see Adverse Reactions (6.1)].

• receiving concomitant OATP1B1 inhibitors [see Drug Interactions (7)].

• with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment [see Use in Specific Populations (8.6)].

​• with moderate or severe renal impairment (eGFR less than 60 mL/min/1.73 m2); and in patients with end stage renal disease (ESRD) not yet on dialysis (eGFR less than 15 mL/min/1.73 m2) [see Use in Specific Populations (8.7)].

Discontinue VIBERZI in patients who develop severe constipation [see Warnings and Precautions (5.4)].

Instruct patients if they miss a dose, take the next dose at the regular time and not to take 2 doses at the same time to make up for a missed dose.