Usual Adult Dose for Cutaneous T-cell Lymphoma

400 mg orally once a day; If a patient is intolerant to therapy, the dose may be reduced to 300 mg orally once daily; the dose may be further reduced to 300 mg once daily for 5 consecutive days each week if needed

• This drug should be taken with food.
• Swallow capsules whole; do not open or crush.
• Therapy may be continued as long as there is no evidence of progressive disease or unacceptable toxicity.

Renal Dose Adjustments

Caution recommended.

Liver Dose Adjustments

• Mild to moderate hepatic impairment (bilirubin 1 to 3 times the upper limit of normal (ULN) or AST greater than ULN): Reduce the starting dose to 300 mg orally once daily
• Severe hepatic impairment (bilirubin greater than 3 x ULN): Data not available

Dose Adjustments

If a patient is intolerant to 400 mg once daily, the dose may be reduced to 300 mg orally once daily; the dose may be further reduced to 300 mg once daily for 5 consecutive days each week if needed.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should be taken with food.
• Swallow capsules whole; do not open or crush.
• Direct contact with the powder contained in the capsules with the skin or mucous membranes should be avoided. The area(s) should be washed thoroughly if contact occurs.