Latest Drugs, Latest Approval in Nonsteroidal anti-inflammatory drugs

What are nonsteroidal anti-inflammatory drugs (NSAIDs)?

Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that relieve pain and fever and reduce inflammation.

There are nearly two dozen different NSAIDs available, but they all work in the same way, and that is by blocking a specific group of enzymes called cyclo-oxygenase enzymes, often abbreviated to COX enzymes. These enzymes are responsible for the production of prostaglandins. Prostaglandins are a group of compounds with hormone-like effects that control many different processes such as inflammation, blood flow, and the formation of blood clots.

What are nonsteroidal anti-inflammatory agents used for?

NSAIDs are used to treat mild-to-moderate pain that arises from a wide range of conditions such as headaches, menstruation, migraines, osteoarthritis or rheumatoid arthritis, sprains and strains, and toothache.

Aspirin is a NSAID that is used in small doses to lower the risks of having a heart attack or a stroke caused by a blood clot. It may also be given as a single dose at the time of a heart attack to improve outcomes. This is because it irreversibly inhibits the COX-1 enzyme.

What are the differences between nonsteroidal anti-inflammatory agents?

NSAIDs may be grouped according to their preference for COX-1 and COX-2 enzymes. Those that favor COX-1 are more likely to cause gastrointestinal side effects. Those that favor COX-2 have a higher risk of cardiovascular effects but less gastrointestinal effects. Higher dosages of NSAIDs tend to result in more COX-2 enzyme inhibition (and more cardiovascular side effects), even in those NSAIDs traditionally seen as low risk (such as ibuprofen). NSAIDs with higher activity against COX-2 enzymes should be used with caution in people with cardiovascular disease or at increased risk of cardiovascular disease.

Both types of COX enzymes produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury.

Most NSAIDs inhibit both enzymes to a certain extent.

Name Updated
Flurbiprofen (Flurbiprofen [ flure-bi-proe-fen ]) 17-Aug-2023
Children's motrin (Ibuprofen [ eye-bue-proe-fen ]) 16-Aug-2023
Children's ibuprofen berry (Ibuprofen [ eye-bue-proe-fen ]) 16-Aug-2023
Alivio (Ibuprofen [ eye-bue-proe-fen ]) 16-Aug-2023
Aleve liquid gels (Naproxen [ na-prox-en ]) 16-Aug-2023
Aleve easy open arthritis (Naproxen [ na-prox-en ]) 16-Aug-2023
Aleve back and muscle pain (Naproxen [ na-prox-en ]) 16-Aug-2023
Sulindac (Sulindac [ sul-in-dak ]) 16-Aug-2023
Piroxicam (Piroxicam [ peer-ox-i-kam ]) 16-Aug-2023
Naprelan 500 (Naproxen [ na-prox-en ]) 16-Aug-2023
Naprelan (Naproxen [ na-prox-en ]) 16-Aug-2023
Children's advil (Ibuprofen [ eye-bue-proe-fen ]) 15-Aug-2023
Advil migraine (Ibuprofen [ eye-bue-proe-fen ]) 15-Aug-2023
Wal-profen (Ibuprofen [ eye-bue-proe-fen ]) 15-Aug-2023
Motrin migraine pain (Ibuprofen [ eye-bue-proe-fen ]) 14-Aug-2023
Motrin infant drops (Ibuprofen [ eye-bue-proe-fen ]) 14-Aug-2023
Motrin ib migraine (Ibuprofen [ eye-bue-proe-fen ]) 14-Aug-2023
Motrin childrens (Ibuprofen [ eye-bue-proe-fen ]) 14-Aug-2023
Ibuprohm (Ibuprofen [ eye-bue-proe-fen ]) 14-Aug-2023
Fenoprofen (Fenoprofen [ fen-oh-proe-fen ]) 14-Aug-2023
Esomeprazole and naproxen (Esomeprazole and naproxen [ ee-soe-mep-ra-zole-and-na-prox-en ]) 14-Aug-2023
Ec-naprosyn (Naproxen [ na-prox-en ]) 14-Aug-2023
Mefenamic acid (Mefenamic acid [ me-fe-nam-ik ]) 13-Aug-2023
Meclofenamate (Meclofenamate [ mek-loe-fen-a-mate ]) 13-Aug-2023
Ketorolac (oral/injection) (Ketorolac (oral/injection) [ kee-toe-role-ak ]) 13-Aug-2023
Ketorolac (nasal) (Ketorolac (nasal) [ kee-toe-role-ak ]) 13-Aug-2023
Ibuprofen injection (Ibuprofen injection [ eye-bue-proe-fen ]) 13-Aug-2023
Famotidine and ibuprofen (Famotidine and ibuprofen [ fam-oh-ti-deen-and-eye-bue-proe-fen ]) 13-Aug-2023
Diflunisal (Diflunisal [ dye-floo-ni-sal ]) 13-Aug-2023
Diclofenac and misoprostol (Diclofenac and misoprostol [ dye-kloe-fen-ak-and-mye-so-prost-ole ]) 13-Aug-2023
Tolmetin (Tolmetin [ tol-met-in ]) 12-Aug-2023
Smart sense children's ibuprofen (Ibuprofen [ eye-bue-proe-fen ]) 12-Aug-2023
Oxaprozin (Oxaprozin [ ox-a-proe-zin ]) 11-Aug-2023
Naproxen (Naproxen [ na-prox-en ]) 11-Aug-2023
Nabumetone (Nabumetone [ na-bue-me-tone ]) 11-Aug-2023
Meloxicam (Meloxicam (oral/injection) [ mel-oks-i-kam ]) 11-Aug-2023
Proprinal (Ibuprofen [ eye-bue-proe-fen ]) 05-Aug-2023
Tivorbex (Indomethacin [ in-doe-meth-a-sin ]) 05-Aug-2023
Anaprox-ds (Naproxen [ na-prox-en ]) 05-Aug-2023
Zorvolex (Diclofenac [ dye-kloe-fen-ak ]) 14-Jul-2023
Zipsor (Diclofenac [ dye-kloe-fen-ak ]) 14-Jul-2023
Vimovo (Esomeprazole and naproxen [ ee-soe-mep-ra-zole-and-na-prox-en ]) 14-Jul-2023
Sprix nasal spray (Ketorolac (nasal) [ kee-toe-role-ak ]) 14-Jul-2023
Prevacid naprapac (Lansoprazole and naproxen [ lan-soe-pra-zole-and-na-prox-en ]) 14-Jul-2023
Neoprofen (Ibuprofen injection [ eye-bue-proe-fen ]) 13-Jul-2023
Nalfon (Fenoprofen [ fen-oh-proe-fen ]) 13-Jul-2023
Motrin ib (Ibuprofen 200mg [ eye-bue-proe-fen ]) 13-Jul-2023
Midol ib (Ibuprofen [ eye-bue-proe-fen ]) 13-Jul-2023
Midol extended relief (Naproxen [ na-prox-en ]) 13-Jul-2023
Lofena (Diclofenac [ dye-kloe-fen-ak ]) 13-Jul-2023