Ketorolac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Ketorolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.
You should not use this medicine if you are allergic to ketorolac, or if you have:
-
severe kidney disease;
-
a bleeding or blood clotting disorder;
-
a closed head injury or bleeding in your brain;
-
a stomach ulcer, perforation, or a history of stomach or intestinal bleeding; or
-
if you are breast-feeding a baby; or
-
if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Pentoxifylline or probenecid can interact with ketorolac and should not be used at the same time.
Do not use ketorolac nasal if you are already taking aspirin or other NSAIDs, or using other forms of ketorolac (such as injections or pills you take by mouth).
Tell your doctor if you have ever had:
-
heart disease, high blood pressure;
-
a heart attack, stroke, or blood clot;
-
stomach ulcers or bleeding;
-
ulcerative colitis or Crohn's disease;
-
asthma;
-
liver or kidney disease;
-
fluid retention; or
-
if you smoke.
If you are pregnant, you should not use ketorolac nasal unless your doctor tells you to. Using an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
Ketorolac may affect ovulation, which could temporarily affect fertility (your ability to have children).
Tell your doctor if you are breastfeeding.
Ketorolac nasal is not approved for use by anyone younger than 2 years old.