Fluorouracil is used to treat cancer of the colon, rectum, breast, stomach, or pancreas.

Fluorouracil is often given in combination chemotherapy with other cancer drugs.

Fluorouracil may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency;
• heart problems; or
• bone marrow depression.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Fluorouracil can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using fluorouracil.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because fluorouracil can harm an unborn baby.

You should not breastfeed while using this medicine.

Use Adrucil (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• fever (take your temperature each day while receiving fluorouracil);
• severe or ongoing diarrhea;
• vision problems;
• confusion, problems with balance or muscle movement;
• painful mouth sores, red or swollen gums, trouble swallowing, talking, or eating;
• bone marrow suppression--dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;
• "hand and foot syndrome"--pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;
• heart problems--chest pain or pressure, pain spreading to your jaw or shoulder, irregular heartbeats, nausea, sweating, feeling dizzy or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• diarrhea;
• mouth sores;
• heart problems; or
• bone marrow suppression.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.