Generic name: Fosnetupitant and palonosetron (injection)
Pregnancy & Lactation: Risk data not available
What is Akynzeo Injection?
Fosnetupitant and palonosetron is used with other medications to prevent nausea and vomiting that may happen during and after chemotherapy in adults.
Fosnetupitant and palonosetron is not used to treat nausea and vomiting that you already have.
Fosnetupitant and palonosetron may also be used for purposes not listed in this medication guide.
Warnings
Tell your doctor if you have ever had:
- an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron, ondansetron, palonosetron, or granisetron; or
- severe liver or kidney disease.
Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with fosnetupitant and palonosetron could cause a serious condition called serotonin syndrome.
Fosnetupitant and palonosetron may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
How should I use Akynzeo Injection
Use Akynzeo Injection (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Fosnetupitant and palonosetron is usually given before the start of chemotherapy treatment.
Fosnetupitant and palonosetron is given as an infusion into a vein. A healthcare provider will give you this injection.
You may be given other medications to further help prevent nausea and vomiting. Keep taking these medicines for as long as your doctor has prescribed.
You may need blood tests after receiving fosnetupitant and palonosetron if you also take a blood thinner called warfarin.
In a medical setting you are not likely to miss a dose.
Akynzeo Injection side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
- headache;
- feeling weak or tired;
- skin redness; or
- upset stomach, constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Akynzeo Injection?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.