This medication guide is specific to the Alvaiz brand of eltrombopag. Do not use Alvaiz in place of other brands of eltrombopag.

Alvaiz is used to treat low platelet levels in adults and children at least 6 years old with chronic immune thrombocytopenia. Alvaiz is given after other treatments did not work or stopped working.

Alvaiz is used in adults to treat severe aplastic anemia after other treatments did not work or stopped working.

Alvaiz is also used to treat low platelet levels in the blood of adults with chronic hepatitis C before and during treatment with interferon.

Alvaiz is not to be used in people:

• who have a pre-cancerous condition called myelodysplastic syndrome (MDS);
• who have low platelet levels in blood (caused by certain other medical conditions or diseases); or
• who need platelet levels to normalize.

Your doctor will determine if you are able to take Alvaiz.

Alvaiz may also be used for purposes not listed in this medication guide.

Tell your doctor if you have or have ever had:

• a blood clot;
• pre-cancerous condition called myelodysplastic syndrome (MDS) or blood cancer;
• bleeding or blood clotting disorder;
• trouble swallowing;
• cataracts;
• a surgery to remove your spleen;
• if you are of East or Southeast Asian descent;
• to use any medicine to treat hepatitis C; or
• liver disease.

It is not known if Alvaiz will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should still use effective birth control while using Alvaiz and for at least 7 days after your last dose.

Do not breastfeed while using this medicine.

Use Alvaiz (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

You may develop a blood clot while you are using Alvaiz. Call your doctor or get emergency medical help if you have:

• signs of a stroke--sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;
• signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, dizziness, coughing up blood;
• signs of a blood clot deep in the body--pain, swelling, or warmth in one leg; or
• signs of a blood clot in the stomach--severe stomach pain, vomiting, diarrhea.

Call your doctor at once if you have any of these other side effects, even if they occur after your treatment ends.

• easy bruising, unusual bleeding, pinpoint purple or red spots under your skin;
• blurred or cloudy vision, seeing halos around lights, vision changes;
• low red blood cells (anemia)--pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet; or
• liver problems--confusion, tiredness, right-sided upper stomach pain, swelling around your midsection, dark urine, jaundice (yellowing of the skin or eyes).

Your treatment may be permanently discontinued if you have certain side effects.

Common side effects may include:

• nausea, diarrhea;
• fever;
• cough;
• headache, tiredness;
• low red blood cells (anemia); or
• abnormal bone marrow or liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ask your doctor before taking an antacid, and take only the type your doctor recommends.

Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.