Amlodipine is a calcium channel blocker. Olmesartan is an angiotensin II receptor blocker (sometimes called an ARB).

Amlodipine and olmesartan is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Amlodipine and olmesartan may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to amlodipine or olmesartan.

If you have diabetes, do not use amlodipine and olmesartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking amlodipine and olmesartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

• kidney disease;
• liver disease;
• coronary artery disease;
• angina (chest pain), congestive heart failure;
• high levels of potassium in your blood;
• if you are on a low-salt diet;
• if you are 75 years or older; or
• if you recently had a heart attack.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using this medicine.

Amlodipine and olmesartan is not approved for use by anyone younger than 18 years old.

Use Amlodipine And Olmesartan (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

When you first start taking this medicine, you may have new or worsening chest pain (angina), or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Call your doctor at once if you have:

• new or worsening chest pain;
• swelling in your hands or feet, rapid weight gain;
• severe or ongoing diarrhea with weight loss;
• pounding heartbeats or fluttering in your chest;
• a light-headed feeling, like you might pass out; or
• high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common side effects include swelling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.