Amlodipine is a calcium channel blocker. Hydrochlorothiazide is a thiazide diuretic (water pill). Olmesartan is an angiotensin II receptor blocker (sometimes called an ARB).

Amlodipine, hydrochlorothiazide, and olmesartan is a combination medicine used to treat high blood pressure (hypertension).

This medicine is usually given after other blood pressure medication did not work.

Amlodipine, hydrochlorothiazide, and olmesartan may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to amlodipine, hydrochlorothiazide, or olmesartan, or:

• if you are allergic to any sulfa drug; or
• if you are unable to urinate.

If you have diabetes, do not use amlodipine, hydrochlorothiazide, and olmesartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking this medicine with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

• kidney disease;
• liver disease;
• heart disease;
• an electrolyte imbalance (such as high levels of calcium, or low levels of potassium or magnesium in your blood);
• low blood pressure;
• glaucoma;
• lupus;
• gout;
• diabetes; or
• a penicillin allergy.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using this medicine.

Use Amlodipine, Hydrochlorothiazide, And Olmesartan (Tribenzor) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• worsening chest pain;
• a light-headed feeling, like you might pass out;
• an unusual skin rash;
• pain or burning when you urinate;
• severe or ongoing diarrhea with weight loss;
• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
• signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, lack of energy, irregular heartbeats, numbness or tingling, loss of movement.

Common side effects may include:

• dizziness;
• headache, tired feeling;
• swelling in your hands or feet;
• nausea, diarrhea;
• runny or stuffy nose, sore throat;
• muscle spasms;
• swollen joints; or
• painful urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Drinking alcohol with this medicine can cause side effects.

Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.