Amoxicillin and vonoprazan (Voquezna Dual Pak) is a combination medicine used to prevent stomach ulcer in adults caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin and vonoprazan may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to amoxicillin or vonoprazan, or similar medicines such as:

• a penicillin antibiotic, including ampicillin, Augmentin, Principen, Timentin, Trimox, and others; or
• a cephalosporin antibiotic such as cefdinir, cefprozil, cefuroxime, cephalexin, Duricef, Omnicef, Cefzil, Keflex, Spectracef, and others.

Some drugs should not be used with amoxicillin and vonoprazan. Your treatment plan may change if you also use:

• rilpivirine-containing products.

Tell your doctor if you have ever had:

• liver or kidney disease.

It is not known if amoxicillin and vonoprazan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using this medicine. If you use a breast pump during this time, throw out the milk and do not feed it to your baby for at least 2 days after your last dose.

Use Amoxicillin And Vonoprazan (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
• liver problems--swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• kidney problems--swelling, urinating less, feeling tired or short of breath.

Common side effects may include:

• diarrhea, stomach pain;
• vaginal itching or discharge; or
• runny or stuffy nose, sneezing, cough, or sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.