Amoxicillin is a penicillin antibiotic. Omeprazole is a proton pump inhibitor that decreases stomach acid. Rifabutin is an antibiotic that fights bacteria.

Amoxicillin, omeprazole, and rifabutin is a combination medicine that is used to treat Helicobacter pylori (H. pylori) infection in adults.

Amoxicillin, omeprazole, and rifabutin may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to amoxicillin (Amoxil, Augmentin), omeprazole (Prilosec), or rifabutin (Mycobutin).

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with amoxicillin, omeprazole, and rifabutin. Your doctor may change your treatment plan if you also use:

• delavirdine;
• rilpivirine (Juluca); or
• voriconazole.

Tell your doctor if you have ever had:

• an allergic reaction to an antibiotic medicine;
• lupus;
• liver disease;
• kidney disease; or
• mononucleosis.

Amoxicillin, omeprazole, and rifabutin may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

This medicine can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using amoxicillin, omeprazole, and rifabutin, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.

This medicine may affect fertility (ability to have children) in men.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Amoxicillin, omeprazole, and rifabutin is not approved for use by anyone younger than 18 years old.

Use Amoxicillin, Omeprazole, And Rifabutin (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
• a light-headed feeling, like you might pass out;
• easy bruising, unusual bleeding, purple or red spots under your skin;
• eye pain or redness, vision problems, seeing spots, your eyes may be more sensitive to light;
• flu-like symptoms--fever, chills, sweating, tiredness, body aches, vomiting, chest pain, cough, feeling short of breath;
• kidney problems--urinating more or less than usual, fever, nausea, vomiting, blood in your urine, confusion, swelling, rapid weight gain; or
• lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight.

Common side effects may include:

• red, orange, or brown discoloration of your skin, tears, sweat, saliva, urine, or stools;
• indigestion, stomach pain, nausea, vomiting, diarrhea;
• headache;
• discolored urine;
• sore throat;
• rash; or
• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not take this medicine with alcohol.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Avoid wearing soft contact lenses. The rifabutin in this medicine can discolor your tears and could permanently stain contact lenses.