Amphetamine is a central nervous system stimulant that affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Amphetamine is used to treat attention deficit hyperactivity disorder (ADHD).

The Evekeo brand of amphetamine is used to treat ADHD and also narcolepsy. Evekeo is sometimes used to treat obesity in people who have not lost weight with diets or other treatments.

Amphetamine is not approved for use in children less than 6 years of age, with the exception of Evekeo (approved for children age 3 and older).

Amphetamine may be habit-forming, and this medicine is a drug of abuse. Tell your doctor if you have had problems with drug or alcohol abuse.

Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Amphetamine may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder.

Amphetamine may cause blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes.

Call your doctor right away if you have: signs of heart problems - chest pain, feeling light-headed or short of breath; signs of psychosis - paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems - unexplained wounds on your fingers or toes.

Amphetamine comes as an immediate-release tablet (Evekeo), an orally disintegrating tablet (tablet that dissolves quickly in the mouth; Evekeo ODT), an extended-release (long-acting) orally disintegrating tablet (Adzenys XR), and as an extended-release (long-acting) suspension (Adzenys ER, Dyanavel XR) to take by mouth. The extended-release suspension is usually taken once daily in the morning with or without food. The orally disintegrating tablet is usually taken once daily in the morning with or without food or liquid. The extended-release orally disintegrating tablet is usually taken once daily in the morning with or without food. For treatment of ADHD or narcolepsy, the immediate-release tablet is usually taken with or without food one to three times daily, 4 to 6 hours apart, with the first dose in the morning. For weight loss, the immediate-release tablet is usually taken 30 to 60 minutes before meals. Amphetamine should not be taken in the late afternoon or evening because it may cause difficulty falling asleep or staying asleep. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amphetamine exactly as directed.

Swallow the extended-release tablets whole, do not chew or crush them.

Do not try to push the orally disintegrating tablet (Evekeo ODT) or the extended-release orally disintegrating tablet (Adzenys XR) through the blister pack foil. Instead, use dry hands to peel back the foil packaging. Immediately take out the tablet and place it in your mouth. The tablet will quickly dissolve and can be swallowed with saliva. No water is needed to swallow the tablet.

Shake the extended-release suspension (Adzenys ER, Dyanavel XR) well before each use to mix the medication evenly.

Do not add the extended-release suspension (Adzenys ER) to food or mix it with other liquids.

It is important to use an oral syringe (measuring device) to accurately measure and take your dose of the extended-release suspension. Ask your pharmacist for a device if it was not provided. Wash the oral syringe thoroughly after each use.

If you or your child are taking amphetamine for ADHD, your doctor will probably start you on a low dose of amphetamine and increase your dose gradually, every 4 to 7 days, depending on the medication. Your doctor may tell you to stop taking amphetamine from time to time to see if the medication is still needed. Follow these directions carefully.

If you are taking amphetamine for narcolepsy, your doctor will probably start you on a low dose of amphetamine and increase your dose gradually, not more often than once every week. Follow these directions carefully.

The medication in each product is absorbed differently by the body, so one amphetamine product cannot be substituted for another product. If you are switching from one product to another, your doctor will prescribe a dose that is best for you.

Take amphetamine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Amphetamine may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Take with or without food.

Shake the oral suspension (liquid). Measure a dose with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Allow the orally disintegrating tablet to dissolve in your mouth without chewing.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.

Your doctor will need to check your progress on a regular basis. Tell any doctor who treats you that you are using this medicine.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Keep your medicine in a place where no one can use it improperly.

Do not keep leftover amphetamine. Ask your pharmacist where to locate a drug take-back disposal program.

You should not use amphetamine if you are allergic to any stimulant medicine, or if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

You may not be able to use amphetamine if you have:

• chest pain or breathing problems caused by heart disease;

• hardening of the arteries;

• moderate to severe high blood pressure;

• overactive thyroid;

• a history of drug abuse; or

• if you are agitated.

Tell your doctor if you also take opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with amphetamine could cause a serious condition called serotonin syndrome.

Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have:

• heart problems or a congenital heart defect;

• high blood pressure; or

• a family history of heart disease or sudden death.

Amphetamine is not approved for use by anyone younger than 3 years old.

To make sure this medicine is safe for you, tell your doctor if you or anyone in your family has had:

• depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;

• problems with drug or alcohol abuse;

• motor tics (muscle twitches) or Tourette's syndrome;

• kidney disease;

• a thyroid disorder;

• seizures or epilepsy;

• an abnormal brain wave test (EEG);

• coronary artery disease (clogged arteries); or

• blood circulation problems in the hands or feet.

Taking amphetamine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Amphetamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Take the missed dose as soon as you remember, but not late in the day. Skip the missed dose if it is almost evening. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amphetamine could be fatal.

Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, hostility, violence, panic, muscle pain or weakness, stomach cramps, vomiting, or diarrhea. These symptoms may be followed by depression and tiredness. Overdose may also cause seizure or coma.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the orally disintegrating tablet blister packages in the provided plastic sleeves. Store the extended-release orally disintegrating tablet blister packages in the rigid, plastic travel case after removal from the carton. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Talk to your doctor about drinking fruit juice while taking this medicine.

Avoid drinking alcohol.

Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine. These can make you absorb less amphetamine.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Get emergency medical help if you have signs of an allergic reaction to amphetamine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• signs of heart problems - chest pain, trouble breathing, feeling like you might pass out;

• signs of psychosis - hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;

• signs of circulation problems - numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;

• a seizure (convulsions);

• muscle twitches (tics);

• pain or burning when you urinate; or

• changes in your vision.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Amphetamine can affect growth. Tell your doctor if your child is not growing at a normal rate.

Common amphetamine side effects may include:

• increased heart rate;

• mood changes, anxiety, feeling restless or nervous;

• trouble sleeping;

• dry mouth, stomach pain, nausea, vomiting, diarrhea, constipation;

• loss of appetite, weight loss;

• painful urination;

• sexual problems, impotence;

• headache, dizziness;

• fever, weakness; or

• itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Many drugs can interact with amphetamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

Keep all appointments with your doctor. Your doctor may order certain tests to check your body's response to amphetamine and your blood pressure.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking amphetamine.

This prescription is not refillable. Be sure to schedule appointments with your doctor on a regular basis so that you do not run out of medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.