Amphotericin B injection is used to treat serious and potentially life-threatening fungal infections. Amphotericin B injection is in a class of medications called antifungals. It works by slowing the growth of fungi that cause infection.

Amphotericin B injection can cause serious side effects. It should only be used to treat potentially life-threatening fungal infections and not to treat less serious fungal infections of the mouth, throat, or vagina in patients with a normal immune system (body's natural protection against infection).

Talk to your doctor about the risks of receiving amphotericin B injection.

Amphotericin B injection comes as a solid powder cake to be made into a solution and then injected intravenously (into a vein) by a nurse or a doctor. Amphotericin B injection is usually infused (injected slowly) intravenously over a period of 2 to 6 hours once daily. Before you receive your first dose, you may receive a test dose over 20 to 30 minutes to see if you can tolerate the medication. The length of your treatment depends on your general health, how you tolerate the medication, and the type of infection you have.

You may experience a reaction while you receive a dose of amphotericin B injection. These reactions usually happen 1 to 3 hours after starting your infusion and are more severe with the first few doses. Your health care provider may prescribe other medications to decrease these side effects. Tell your doctor immediately if you experience any of these symptoms while you receive amphotericin B injection: fever, chills, loss of appetite, nausea, vomiting, dizziness, breathing problems, or headache.

You may receive amphotericin B injection in a hospital or you may use the medication at home. If you will be using amphotericin B injection at home, your healthcare provider will show you how to infuse the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems infusing amphotericin B injection.

If your symptoms do not improve or get worse while receiving amphotericin B, tell your doctor. If you still have symptoms of infection after you finish amphotericin B injection, tell your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving amphotericin B injection,

• tell your doctor and pharmacist if you are allergic to amphotericin B, any other medications, or any of the ingredients in amphotericin B injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin, or tobramycin (Bethkis, Kitabis Pak, Tobi); antifungals such as clotrimazole, fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), and miconazole (Oravig, Monistat); corticotropin (H.P. Acthar Gel); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); flucytosine (Ancobon); medications for the treatment of cancer such as nitrogen mustard; pentamidine (Nebupent, Pentam); and oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you are receiving leukocyte (white blood cell) transfusions.
• tell your doctor if you have or have ever had kidney disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving amphotericin B injection, call your doctor. Do not breastfeed while receiving amphotericin B injection.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving amphotericin B injection.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• chest pain
• shortness of breath
• dizziness
• loss of consciousness
• fast, irregular, or pounding heartbeat

Unless your doctor tells you otherwise, continue your normal diet.

Amphotericin B injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• stomach pain or cramping
• heartburn
• diarrhea
• weight loss
• bone, muscle, or joint pain
• lack of energy
• redness or swelling at the injection site
• pale skin
• shortness of breath
• dizziness
• headache
• coldness in the hands and feet

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• rash
• blisters or hives
• flushing
• wheezing
• difficulty breathing
• itching
• yellowing of the skin or eyes
• decreased urination

Amphotericin B injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests during your treatment to check your body's response to amphotericin B injection.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.