Aprepitant is used together with other medications to prevent nausea and vomiting that may be caused by chemotherapy.

Aprepitant may also be used in adults to prevent nausea and vomiting after surgery.

Aprepitant is not used to treat nausea and vomiting that you already have.

Aprepitant capsules are for use in adults and children who are at least 12 years old. Aprepitant oral suspension (liquid) can be given to adults and children as young as 6 months old.

Aprepitant may also be used for purposes not listed in this medication guide.

You should not use aprepitant if you are allergic to it.

Some drugs should not be used with aprepitant. Your treatment plan may change if you also use pimozide.

Tell your doctor if you have ever had:

• to use a blood thinner (or a medicine called warfarin) and you have routine "INR" or prothrombin time tests; or
• severe liver disease.

Aprepitant may harm an unborn baby. Tell your doctor if you are pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Aprepitant can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, spermicide, or contraceptive sponge.

Ask your doctor about the best form of birth control while you are using aprepitant.

Keep using the barrier form of birth control for 1 month after your last dose of aprepitant.

Use Aponvie (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

• worsening of your skin condition, skin peeling or sores;
• a light-headed feeling, like you might pass out; or
• fast or slow heart rate.

Common side effects may include:

• stomach pain or discomfort, burping, loss of appetite;
• low blood pressure, headache, dizziness;
• low blood cell counts;
• diarrhea, constipation;
• hiccups, cough;
• abnormal liver function tests;
• dehydration;
• urinary tract infection;
• pain, weakness, or numbness in your arms or legs; or
• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.