Aspirin and omeprazole is a combination medicine used to help lower the risk of heart problems, strokes, or death in people who have had heart problems caused by blood clots.

Aspirin and omeprazole is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin.

Omeprazole helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past.

Aspirin and omeprazole may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to aspirin or omeprazole, or if:

• you are also allergic to medicines like esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;
• you take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey);
• you have had an asthma attack or severe allergic reaction (sneezing, runny or stuffy nose, wheezing, chest pain, shortness of breath) after taking aspirin or another NSAID; or
• if you had breathing problems, kidney problems, or a severe allergic reaction after taking this medicine in the past.

Aspirin and omeprazole should not be used to treat a sudden onset of heart attack or stroke symptoms (chest pain, sudden numbness or weakness, slurred speech).

This medicine is not approved for use by anyone younger than 18 years old. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.

Tell your doctor if you have ever had:

• a bleeding disorder or vitamin K deficiency;
• low levels of magnesium in your blood;
• a habit of drinking more than 3 alcoholic beverages per day;
• liver or kidney disease;
• lupus; or
• if you are of Asian descent.

You may be more likely to have a broken bone in your hip, wrist, or spine while taking this medicine long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine may temporarily affect your ability to get pregnant. Talk with your doctor if this concerns you.

You should not breastfeed while using aspirin and omeprazole.

Use Aspirin And Omeprazole (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe nausea, vomiting, stomach pain, or diarrhea that is watery or bloody;
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• easy bruising, unusual bleeding (such as a nosebleed), or any bleeding that will not stop;
• sudden pain or trouble moving your hip, wrist, or back;
• kidney problems--fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;
• liver problems--stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
• low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or
• new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Taking this medicine long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use this medicine for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common side effects may include:

• heartburn, stomach pain, indigestion;
• nausea, diarrhea; or
• chest pain (may happen when you eat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to aspirin or omeprazole.

Taking regular aspirin together with omeprazole (Prilosec) will not work the same way as taking combination aspirin and omeprazole (Yosprala). Do not substitute this medicine with over-the-counter products.

Drinking alcohol can increase your risk of stomach bleeding.