Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Aspirin, butalbital, caffeine, and codeine may cause serious side effects. Call your doctor at once if you have:
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noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
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a slow heart rate or weak pulse;
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a light-headed feeling, like you might pass out;
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confusion, unusual thoughts or behavior;
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easy bruising or bleeding (nosebleeds, bleeding gums);
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severe constipation;
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symptoms of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
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low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women.
Common side effects include:
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nausea, vomiting, stomach pain, constipation;
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headache, dizziness, drowsiness; or
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feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See more: Aspirin, butalbital, caffeine, and codeine Side Effects