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Home > Drugs > Miscellaneous antibiotics > Atovaquone
Miscellaneous antibiotics

Atovaquone

https://themeditary.com/drug/atovaquone-5993.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 13, 2023  Additional Content by TheMediTary.Com

Generic name: atovaquone [ a-toe-va-kwone ]

Drug class: Miscellaneous antibiotics

Dosage form: oral suspension (750 mg/5 ml)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Mepron

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Atovaquone?

Atovaquone interferes with the reproduction of protozoa (single-cell organisms) that can cause disease in the body.

Atovaquone is used to treat or prevent pneumonia caused by a fungal infection called Pneumocystis carinii (also called Pneumocystis jiroveci).

atovaquone is for use in adults and children who are at least 13 years old.

Atovaquone may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

How should I take Atovaquone

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take with food.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

If you are taking a pre-measured dose from a foil pouch, use all of the medicine in the pouch. You may drink it directly from the pouch or pour it into a spoon or cup before taking.

Take atovaquone for the full prescribed length of time, even if your symptoms quickly improve.

Store at cool room temperature away from moisture and heat. Do not freeze.

Dosing information

Usual Adult Dose for Pneumocystis Pneumonia:

750 mg orally twice a day for 21 days
Alternative therapy may be needed if arterial blood gas values do not improve or worsen after 7 to 10 days of therapy, or if the clinical status declines after 4 days.

Usual Adult Dose for Pneumocystis Pneumonia Prophylaxis:

1500 mg orally once a day

Usual Adult Dose for Babesiosis:

750 mg orally twice a day with azithromycin (500 to 600 mg on day 1, followed by 250 to 600 mg once a day thereafter or 1000 mg once a day for 3 days, followed by 500 mg once a day thereafter) for 7 to 10 days

Usual Adult Dose for Malaria:

500 to 750 mg orally every 12 hours for 7 days; should be used in combination with other antimalarial agents

Usual Adult Dose for Toxoplasmosis:

750 mg orally every 6 hours for 2 to 6 months
Similar doses given every 6 to 8 hours are used for toxoplasmosis maintenance therapy.

Atovaquone is considered second-line therapy for toxoplasmosis. It should be administered in combination with pyrimethamine and leucovorin, with sulfadiazine, or as a single agent in patients intolerant of pyrimethamine with sulfadiazine.

Usual Pediatric Dose for Pneumocystis Pneumonia:

1 month to 12 years: 20 mg/kg orally twice a day
13 years or older: 750 mg orally twice a day for 21 days

Maximum dose: 1500 mg/day

Usual Pediatric Dose for Pneumocystis Pneumonia Prophylaxis:

1 to 3 months: 30 mg/kg orally once a day
4 months up to 2 years: 45 mg/kg orally once a day
2 to 12 years: 30 mg/kg orally once a day
13 years or older: 1500 mg orally once a day

Maximum dose: 1500 mg/day

Usual Pediatric Dose for Babesiosis:

1 to 12 years: 20 mg/kg orally twice a day with azithromycin (12 mg/kg once a day) for 7 to 10 days
13 years or older: 750 mg orally twice a day with azithromycin (500 to 600 mg on day 1, followed by 250 to 600 mg once a day thereafter or 1000 mg once a day for 3 days, followed by 500 mg once a day thereafter) for 7 to 10 days

Maximum dose: 1500 mg/day

Detailed Atovaquone dosage information
Atovaquone Dosage information (more detail)

Before Taking

You should not use atovaquone if you are allergic to it.

Tell your doctor if you have ever had:

  • liver disease; or

  • a stomach or intestinal disorder.

It is not known whether atovaquone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze this medication.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Atovaquone?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Atovaquone side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Atovaquone may cause serious side effects. Call your doctor at once if you have:

  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, dark urine, or jaundice (yellowing of the skin or eyes).

Common side effects of atovaquone may include:

  • nausea, vomiting, diarrhea;

  • headache;

  • fever; or

  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Atovaquone Side Effects

What other drugs will affect Atovaquone?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect atovaquone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Atovaquone (Atovaquone [ a-toe-va-kwone ])

Dosage information
Atovaquone Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Miscellaneous antibiotics

Related treatment guides

Pneumocystis Pneumonia
Pneumocystis Pneumonia Prophylaxis
Babesiosis
Malaria
Toxoplasmosis
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Uses Warnings Before Taking Dosage Side effects Interactions
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