It is not likely that other drugs you take orally or inject will have an effect on topically applied tretinoin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Atralin can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Avoid getting Atralin in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use Atralin on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Atralin.

Use this medication for as many days as it has been prescribed for you even if you think it is not working. It may take weeks or months of use before you notice improvement in your skin. If you are using Atralin to treat acne, your condition may get slightly worse for a short time when you first start using the medication. Call your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Do not take by mouth. Atralin is for use only on the skin. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Wash your hands before and after applying Atralin. Wash your skin with mild, non-medicated soap and dry your skin gently. Apply once a day before bedtime.

Squeeze a small amount of gel (about the size of a pea) on your fingertip. Apply Atralin Gel , using a thin layer to cover the entire affected area. Smooth the gel into your skin.

Do not put Atralin Gel, near your mouth, eyes, on the corners of your nose, or on open sores. Spread the gel away from these areas when putting the gel on your skin.

Do not use more Atralin Gel than your doctor has prescribed. Do not use the gel more often than your doctor has told you. Using too much gel may irritate or increase the irritation of your skin, and will not give faster or better results.

You may not see improvement right away. Atralin Gel may work better for some patients than for others.

Do not wash the treated area for at least 1 hour after applying Atralin. Avoid the use of other skin products on the treated area for at least 1 hour following an application.

Atralin should be used as part of a complete skin care program that includes avoiding sunlight and using an effective sunscreen and protective clothing.

Use this medication for the full prescribed length of time, even if you think it is not working.

It may take up to several weeks before you notice improvement in your skin. Keep using the medication as directed and tell your doctor if your symptoms do not improve. If you are using Atralin to treat acne, your condition may get slightly worse for a short time when you first start using the medication.

Call your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Atralin gel is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

You should not use Atralin if you are allergic to tretinoin.

It is not known whether Atralin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether tretinoin topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid exposure to sunlight or tanning beds. Atralin can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors, even on a cloudy day.

Avoid getting this medication in your eyes, nose, mouth, or in the creases of your nose.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid using other medications on the areas you treat with Atralin unless your doctor tells you to.

Get emergency medical help if you have any signs of an allergic reaction to Atralin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Atralin and call your doctor at once if you have:

• severe burning, stinging, or irritation of treated skin;

• severe redness, swelling, blistering, peeling, or crusting;

Your skin may be more sensitive to weather extremes such as cold and wind while using this medicine.

Common Atralin side effects may include:

• mild warmth or stinging where the medicine was applied; or

• changes in color of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not use skin products that contain benzoyl peroxide, sulfur, resorcinol, or salicylic acid unless otherwise directed by your doctor. These products can cause severe skin irritation if used with Atralin.