Belantamab mafodotin is used to treat multiple myeloma in adults. This medicine is given after at least 4 other treatments did not work or have stopped working.

Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Belantamab mafodotin is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

Belantamab mafodotin may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• problems with your eyes;
• vision problems; or
• bleeding problems.

You may need to have a negative pregnancy test before starting this treatment.

Belantamab mafodotin can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, do not use belantamab mafodotin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 6 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using belantamab mafodotin.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because belantamab mafodotin can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

Use Belantamab Mafodotin (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection (infusion reaction). Tell your caregiver if you feel dizzy, tired, nauseated, light-headed, itchy, feverish, chilled, sweaty, short of breath, or have racing heartbeats, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

• sudden vision loss;
• easy bruising, unusual bleeding; or
• signs of bleeding in the brain--weakness, dizziness, confusion, numbness or tingling on one side of the body, loss of movement in your face.

Tell your eye doctor if you have any eye problems, changes in your vision, dry eyes, or vision loss.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• vision changes;
• eye changes found during an eye exam;
• infusion reaction;
• abnormal lab tests;
• fever, tiredness; or
• nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not wear contact lenses without your doctor's advice while you are receiving belantamab mafodotin.