Generic name: benazepril [ ben-ay-ze-pril ]
Drug class: Angiotensin Converting Enzyme Inhibitors
Dosage form: oral tablet (10 mg; 20 mg; 40 mg; 5 mg)
Availability: Prescription only
Pregnancy & Lactation: Risk data available
Brand names: Lotensin
What is Benazepril?
Benazepril is used alone or in combination with other medications to treat high blood pressure in adults and children at least 6 years old.
Lowering blood pressure may lower your risk of a stroke or heart attack.
Benazepril may also be used for purposes not listed in this medication guide.
Warnings
Do not use if you are pregnant. Stop using benazepril and tell your doctor right away if you become pregnant.
Tell your doctor about all your other medicines. Some drugs should not be used with benazepril.
How should I take Benazepril
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take benazepril with or without food.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking benazepril. This can lead to very low blood pressure, an electrolyte imbalance, or kidney failure.
Your blood pressure will need to be checked often and you may need frequent blood tests. Your treatment may also include diet, exercise, lifestyle changes, and other medications. Follow your doctor's instructions very carefully.
Tell your doctor if you have a planned surgery.
Keep using benazepril even if you feel well. High blood pressure often has no symptoms.
Store tightly closed at room temperature, away from moisture and heat.
Dosing information
Usual Adult Dose for Hypertension:
Initial dose: With a diuretic: 5 mg orally once a day; without a diuretic: 10 mg orally once a day
Maintenance dose: 20 to 40 mg/day orally as a single dose or in two equally divided doses
Maximum dose: 80 mg/day
Comments:
-The divided dose regimen was more effective in controlling pre-dosing blood pressure.
-If discontinuing a diuretic prior to initiating this drug to reduce the likelihood of hypotension, conclude diuretic therapy 2 to 3 days prior to starting this drug.
Usual Pediatric Dose for Hypertension:
6 YEARS OR OLDER:
Initial dose: 0.2 mg/kg orally once a day as monotherapy
Maximum dose: 0.6 mg/kg; 40 mg/day
Comments:
-Doses between 0.1 and 0.6 mg/kg once a day have been studied; doses greater than 0.1 mg/kg were shown to reduce blood pressure; doses above 0.6 mg/kg or 40 mg/day have not been studied in pediatric patients.
-Prepare a suspension for pediatric patients who cannot swallow tablets or for whom the calculated dosage does not correspond to available tablet strengths.
Before Taking
You should not use benazepril if you are allergic to it or to any other ACE (angiotensin converting enzyme) inhibitor such as captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.
Do not take benazepril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use benazepril together with any medication that contains aliskiren (a blood pressure medicine).
Do not take benazepril if you have a history of angioedema (severe allergic reaction).
Tell your doctor if you have ever had:
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heart disease, heart problems such as a recent heart attack;
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stomach pain;
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low blood pressure;
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if you are on a low-salt diet;
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diabetes;
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liver disease; or
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kidney disease (or if you are on dialysis).
You may also need to avoid taking benazepril with aliskiren if you have kidney disease.
Stop using this medicine and tell your doctor right away if you become pregnant. Benazepril can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.
Do not breastfeed.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What special dietary instructions should I follow?
Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
What should I avoid while using Benazepril?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Do not take potassium supplements or use salt substitutes, unless your doctor has told you to.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Benazepril side effects
Get emergency medical help if you have signs of an allergic reaction: hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat.
Benazepril may cause serious side effects. Call your doctor at once if you have:
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a light-headed feeling, like you might pass out;
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kidney problems--swelling, urinating less, feeling tired or short of breath;
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high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
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liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects of benazepril may include:
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headache; or
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cough.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See more: Benazepril Side EffectsWhat other drugs will affect Benazepril?
Benazepril can harm your kidneys, especially if you also use certain medicines for infections, cancer, or osteoporosis.
Tell your doctor about all your other medicines, especially:
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a diuretic or "water pill" that may increase blood potassium such as spironolactone, triamterene, or amiloride;
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NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
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insulin or diabetes medications;
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medicine to prevent organ transplant rejection such as temsirolimus, sirolimus, or everolimus; or
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heart or blood pressure medication.
This list is not complete. Other drugs may affect benazepril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to benazepril. Your doctor may order certain lab tests to check your body's response to benazepril.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Combination Products
- Lotrel® (containing Benazepril, Amlodipine)