Penicillin G benzathine and penicillin G procaine is a combination antibiotic that is used to treat infections caused by bacteria, including strep, pneumonia, and scarlet fever.

Penicillin G benzathine and penicillin G procaine may also be used for purposes not listed in this medication guide.

You should not be treated with this medicine if you are allergic to penicillin or procaine.

Tell your doctor if you have ever had:

• an allergic reaction to a cephalosporin antibiotic (Keflex, Omnicef, and others);
• any type of allergy;
• asthma or breathing problems;
• a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;
• heart disease; or
• kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

Use Bicillin C-R (Intramuscular) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur if the medicine has been accidentally injected near a vein or nerve. Tell your caregivers right away if you feel light-headed or if you have:

• slow heart rate, weak pulse, slow breathing (breathing may stop);
• pain, numbness, tingling, burning, or feeling cold;
• pale or mottled skin, blue-colored lips, fingers, or toes;
• severe pain or swelling in your lower leg;
• weakness in your arms or legs; or
• blistering, peeling, discoloration, or painful skin changes where the medicine was injected.

Also call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
• confusion, agitation, hallucinations (seeing or hearing things that are not real), extreme fear;
• a seizure;
• pain, swelling, warmth, redness, bruising, bleeding, or a lump where the medicine was injected;
• pale or yellowed skin, bruising or bleeding, dark colored urine;
• urination problems; or
• signs of a new infection--fever, chills, mouth sores, vaginal itching or discharge.

Seek medical attention right away if you develop a serious condition called methemoglobinemia. Symptoms include headache, fast heartbeats, shortness of breath, feeling tired or light-headed, or skin that looks pale, gray, or blue-colored.

Common side effects may include:

• nausea, vomiting, diarrhea;
• itching, sweating, allergic reaction;
• flushing (sudden warmth, redness, or tingly feeling);
• feeling anxious or nervous;
• headache, dizziness, drowsiness; or
• pain, swelling, or bruising where an injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid taking anti-diarrhea medicine without first asking your doctor. Diarrhea may be a sign of a new infection.