Brimonidine and brinzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Brimonidine and brinzolamide ophthalmic (for the eyes) is a combination medicine used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine and brinzolamide ophthalmic may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to brimonidine or brinzolamide.

Brimonidine and brinzolamide ophthalmic should not be given to a child younger than 2 years old.

To make sure brimonidine and brinzolamide ophthalmic is safe for you, tell your doctor if you have:

• kidney disease;
• liver disease;
• congestive heart failure, coronary artery disease, history of stroke or blood clot;
• high or low blood pressure;
• circulation problems, such as Raynaud's syndrome (numbness or cold feeling in your fingers or toes);
• depression;
• an allergy to sulfa drugs; or
• narrow-angle glaucoma.

FDA pregnancy category C. It is not known whether brimonidine and brinzolamide ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether brimonidine and brinzolamide ophthalmic passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Use Brimonidine And Brinzolamide Ophthalmic (Ophthalmic) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may have other signs of allergic reaction that develop more slowly while using this medicine. Call your doctor if you have:

• sudden liver failure--nausea, vomiting, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), confusion, rapid weight gain, (especially in your midsection);
• bone marrow suppression--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing, pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Stop using this medicine and call your doctor at once if you have:

• blurred vision, tunnel vision, eye pain, or seeing halos around lights; or
• eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection).

Common side effects may include:

• blurred vision;
• mild itching, redness, or irritation of your eyes; or
• dry mouth, unpleasant taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.