Brimonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Timolol is a beta-blocker that also reduces pressure inside the eye.

Brimonidine and timolol ophthalmic (for the eyes) is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine and timolol ophthalmic may also be used for purposes not listed in this medication guide.

You should not use brimonidine and timolol ophthalmic if you are allergic to it, or if you have:

• a history of asthma or chronic obstructive pulmonary disease (COPD); or
• a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint.

To make sure brimonidine and timolol ophthalmic is safe for you, tell your doctor if you have:

• congestive heart failure, coronary artery disease, history of stroke or blood clot;
• high or low blood pressure, circulation problems (such as Raynaud's syndrome);
• depression;
• diabetes (using brimonidine and timolol ophthalmic may make it harder for you to tell when you have low blood sugar);
• a thyroid disorder;
• any allergies;
• myasthenia gravis; or
• a history of glaucoma or increased pressure inside your eye.

FDA pregnancy category C. It is not known whether brimonidine and timolol ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Timolol ophthalmic can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medicine to a child without medical advice.

Use Brimonidine And Timolol Ophthalmic (Ophthalmic) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• slow or uneven heart rate;
• pounding heartbeats or fluttering in your chest;
• shallow breathing, feeling like you might pass out;
• severe swelling, redness, or discomfort in or around your eye;
• eye pain or increased watering; or
• numbness or tingly feeling in your hands or feet.

Common side effects may include:

• drowsiness, tired feeling;
• mild itching, redness, or irritation of your eyes; or
• mild stinging or burning when using the eye drops.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Do not use other eye medications unless your doctor tells you to.