Bumetanide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease. Bumetanide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

Bumetanide is a strong diuretic ('water pill') and may cause dehydration and electrolyte imbalance. It is important that you take it exactly as told by your doctor. If you experience any of the following symptoms, call your doctor immediately: rapid, excessive weight loss; decreased urination; dry mouth; thirst; nausea; vomiting; weakness; drowsiness; confusion; muscle pain or cramps; or rapid or pounding heartbeats.

Bumetanide comes as a tablet to take by mouth. It usually is taken once a day. When used to treat edema, a second or third dose may be given every 4 to 5 hours depending on the amount of swelling. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bumetanide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Bumetanide controls edema but does not cure it. Continue to take bumetanide even if you feel well. Do not stop taking bumetanide without talking to your doctor.

Before taking bumetanide,

• tell your doctor and pharmacist if you are allergic to bumetanide, sulfonamide medications, any other medications, or any ingredients in bumetanide tablets. Ask your pharmacist or check the patient information for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications for high blood pressure; aminoglycoside antibiotics such as amikacin, gentamicin (Garamycin), or tobramycin (Bethkis, Tobi); corticosteroids (e.g., prednisone), digoxin (Lanoxin); indomethacin (Indocin, Tivorbex); lithium (Lithobid), and probenecid (Probalan, Probenemid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have kidney disease. Your doctor may tell you not to take bumetanide.
• tell your doctor if you have or have ever had diabetes, or heart, or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not breast-feed while taking this medicine. If you become pregnant while taking bumetanide, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking bumetanide.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• weakness
• dizziness
• confusion
• extreme tiredness
• loss of appetite
• vomiting
• stomach cramps

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

If your doctor prescribes a low-salt or low-sodium diet, or to eat or drink increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet, follow these instructions carefully.

Tell your doctor if any of these symptoms are severe or do not go away:

• frequent urination
• dizziness
• upset stomach
• diarrhea

Some side effects can be serious. If you have any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment::

• ringing in ears
• loss of hearing
• unusual bleeding or bruising
• severe rash with peeling skin
• difficulty breathing or swallowing
• hives

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Bumetanide is also sometimes used to treat high blood pressure. Talk to your doctor about the risks of using this medication for your condition.

This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Keep all appointments with your doctor and the laboratory.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking bumetanide.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.