Bupropion and dextromethorphan is used in adults to treat major depressive disorder.

Bupropion and dextromethorphan may also be used for purposes not listed in this medication guide.

You should not use bupropion and dextromethorphan if you are allergic to it, or if you have:

• a seizure disorder;
• an eating disorder such as anorexia or bulimia; or
• if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use bupropion and dextromethorphan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine. Wait at least 14 days after stopping an MAO inhibitor before you take bupropion and dextromethorphan.

Tell your doctor if you have ever had:

• low blood sodium;
• a stroke;
• a head injury, seizures, or brain or spinal cord tumor;
• glaucoma;
• heart disease, high blood pressure, or a heart attack;
• diabetes;
• kidney or liver disease;
• depression, bipolar disorder, or other mental illness;
• if you have a history of falls; or
• if you have alcoholism or drug addiction.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion and dextromethorphan on the baby.

Bupropion and dextromethorphan may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using this medicine, and for at least 5 days after your last dose.

Use Bupropion And Dextromethorphan (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

• seizures;
• changes in your vision, eye pain or redness;
• paranoia (feeling that people are against you), hallucinations (see or hear things that are not there), delusions (belief that you are someone else), or feeling confused; OR
• serotonin syndrome--agitation, hallucinations, fever, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, diarrhea.

Common side effects may include:

• dizziness;
• headache;
• diarrhea;
• drowsiness;
• dry mouth;
• excessive sweating; or
• sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid drinking alcohol.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.