Bupropion is an antidepressant medicine that can also decrease appetite. Naltrexone is usually given to block the effects of opioids or alcohol in people with addiction problems. Naltrexone may also curb hunger and food cravings.

Bupropion and naltrexone is a combination medicine used to help manage weight in obese or overweight adults with weight-related medical problems. This medicine is used together with diet and exercise.

Bupropion and naltrexone will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol.

Contrave is not approved to treat depression or other psychiatric conditions, or to help you quit smoking.

Bupropion and naltrexone may also be used for purposes not listed in this medication guide.

Do not use this medicine if you are pregnant. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Tell your doctor right away if you become pregnant.

You should not use this medicine if you are allergic to bupropion or naltrexone, or if you have:

• untreated or uncontrolled high blood pressure;
• an eating disorder (anorexia or bulimia);
• a history of seizures;
• opioid addiction or withdrawal (or if you take methadone or buprenorphine);
• if you take other forms of bupropion (Wellbutrin, Aplenzin, Budeprion, Forfivo, Zyban, and others); or
• if you have suddenly stopped using alcohol, seizure medication, or a sedative such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use opioid medication for a minimum of 7 to 10 days before starting bupropion and naltrexone.

Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion and naltrexone. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Tell your doctor if you have ever had:

• depression, bipolar disorder, or mental illness;
• suicidal thoughts or actions;
• a head injury;
• a tumor or infection in your brain or spinal cord;
• diabetes or low blood sugar;
• low sodium levels;
• liver or kidney disease;
• heart disease, high blood pressure, heart attack, or stroke; or
• drug addiction, or if you normally drink a lot of alcohol.

Some young people have thoughts about suicide when first taking bupropion. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

You should not breastfeed while using this medicine.

This medicine is not approved for use by anyone younger than 18 years old.

Use Bupropion And Naltrexone (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: fever, swollen glands, mouth sores, muscle or joint pain; hives, rash or itching; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, severe drowsiness, or if you are hard to wake up.

Stop taking this medicine and call your doctor right away if you have:

• severe headache, blurred vision, pounding in your neck or ears, fast heartbeats;
• a seizure (convulsions);
• blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• changes in mood or behavior--anxiety, depression, panic attacks, trouble sleeping, agitation, thoughts about suicide or hurting yourself;
• a manic episode--racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative;
• liver problems--upper stomach pain, tiredness, dark urine, jaundice (yellowing of the skin or eyes); or
• severe skin reaction--fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling.

Older adults may be more likely to have certain side effects.

Common side effects may include:

• nausea, vomiting, diarrhea, constipation;
• headache, dizziness;
• dry mouth; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can also cause seizures in a regular drinker who suddenly stops drinking.

Follow your doctor's instructions about any restrictions on food, beverages, or activity. Do not take other weight-loss products or diet pills unless your doctor has told you to.

Do not use opioid medication, methadone, heroin, or other street drugs while you are taking bupropion and naltrexone. Doing so could result in dangerous effects, including coma and death.