BuPROPion (Eqv-Zyban Advantage Pack) is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of BuPROPion (Eqv-Zyban Advantage Pack) is used to help people stop smoking by reducing cravings and other withdrawal effects.

BuPROPion (Eqv-Zyban Advantage Pack) may also be used for purposes not listed in this medication guide.

You should not take BuPROPion (Eqv-Zyban Advantage Pack) if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

Do not use BuPROPion (Eqv-Zyban Advantage Pack) within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Too much of this medicine can increase your risk of a seizure.

You may take BuPROPion (Eqv-Zyban Advantage Pack) with or without food.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

You should not change your dose or stop using BuPROPion (Eqv-Zyban Advantage Pack) suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using BuPROPion (Eqv-Zyban Advantage Pack).

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the first 2 weeks of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 to 12 weeks.

Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.

Some people taking BuPROPion (Eqv-Zyban Advantage Pack) (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with BuPROPion (Eqv-Zyban Advantage Pack).

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.

Smoking cessation may also cause new or worsening mental health problems, such as depression.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use BuPROPion (Eqv-Zyban Advantage Pack).

Store at room temperature away from moisture, heat, and light.

You should not take BuPROPion (Eqv-Zyban Advantage Pack) if you are allergic to it, or if you have:

• a seizure disorder;

• an eating disorder such as anorexia or bulimia; or

• if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take BuPROPion (Eqv-Zyban Advantage Pack). A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take BuPROPion (Eqv-Zyban Advantage Pack) to treat more than one condition at a time. If you take BuPROPion (Eqv-Zyban Advantage Pack) for depression, do not also take BuPROPion (Eqv-Zyban Advantage Pack) (Eqv-Zyban Advantage Pack) to quit smoking.

BuPROPion (Eqv-Zyban Advantage Pack) may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Tell your doctor if you have ever had:

• a head injury, seizures, or brain or spinal cord tumor;

• narrow-angle glaucoma;

• heart disease, high blood pressure, or a heart attack;

• diabetes;

• kidney or liver disease (especially cirrhosis);

• depression, bipolar disorder, or other mental illness; or

• if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether BuPROPion (Eqv-Zyban Advantage Pack) will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking BuPROPion (Eqv-Zyban Advantage Pack) without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of BuPROPion (Eqv-Zyban Advantage Pack) on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

BuPROPion (Eqv-Zyban Advantage Pack) is not approved for use by anyone younger than 18 years old.

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of BuPROPion (Eqv-Zyban Advantage Pack) (Eqv-Zyban Advantage Pack) can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.

Drinking alcohol with BuPROPion (Eqv-Zyban Advantage Pack) may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. BuPROPion (Eqv-Zyban Advantage Pack) can also cause seizures in a regular drinker who suddenly stops drinking at the start of treatment with BuPROPion (Eqv-Zyban Advantage Pack).

Avoid driving or hazardous activity until you know how BuPROPion (Eqv-Zyban Advantage Pack) (Eqv-Zyban Advantage Pack) will affect you. Your reactions could be impaired.

Get emergency medical help if you have signs of an allergic reaction (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

BuPROPion (Eqv-Zyban Advantage Pack) may cause serious side effects. Call your doctor at once if you have:

• a seizure (convulsions);

• confusion, unusual changes in mood or behavior;

• blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;

• fast or irregular heartbeats; or

• a manic episode--racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep.

Common side effects of BuPROPion (Eqv-Zyban Advantage Pack) may include:

• dry mouth, sore throat, stuffy nose;

• ringing in the ears;

• blurred vision;

• nausea, vomiting, stomach pain, loss of appetite, constipation;

• sleep problems (insomnia);

• tremors, sweating, feeling anxious or nervous;

• fast heartbeats;

• confusion, agitation, hostility;

• rash;

• weight loss;

• increased urination;

• headache, dizziness; or

• muscle or joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may have a higher risk of seizures if you use certain other medicines while taking BuPROPion (Eqv-Zyban Advantage Pack).

Many drugs can affect BuPROPion (Eqv-Zyban Advantage Pack). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.