Carbidopa and levodopa enteral (Duopa) is a combination medicine used to treat advanced Parkinson's disease.

Carbidopa and levodopa may also be used for purposes not listed in this medication guide.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have ever had:

• a stomach ulcer or stomach surgery;
• low blood pressure, or fainting spells;
• heart disease, high blood pressure, or a heart attack;
• problems falling asleep suddenly during the day;
• problems with muscle movement;
• depression or mental illness;
• glaucoma; or
• nerve problems that cause numbness or tingling in your hands or feet.

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for.

It is not known if this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Duopa can slow breast milk production. Tell your doctor if you are breastfeeding.

Not approved for use by anyone younger than 18 years old.

Use Carbidopa And Levodopa Enteral (Duopa)(Enteral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• nausea, vomiting, stomach pain, fever;
• ongoing constipation, bloody or tarry stools;
• cough, trouble breathing;
• pain, swelling, redness, warmth, or oozing around the tube in your stomach wall;
• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
• a light-headed feeling, like you might pass out;
• chest pain, fast or irregular heartbeats;
• daytime sleepiness or if you suddenly fall asleep after being alert;
• numbness or weakness in your hands or feet; or
• hallucinations, depression or suicidal thoughts.

Some people using Duopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

You may have increased sexual urges, unusual urges to gamble, or other intense urges. Talk with your doctor if this occurs.

Common side effects may include:

• increased blood pressure;
• swelling in your lower legs;
• nausea;
• depression; or
• mouth or throat pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid eating a diet high in iron or protein. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid.

Drinking alcohol with this medicine can cause side effects.